| Type | Description |
|---|---|
| Definition | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-01-19 12:16:00 | Ectopic expression of HECW2 causes the ubiquitination of HP1alpha and beta, thereby targeting them for proteasomal degradation. | 30208514 |
| 2018-12-22 10:28:00 | Results show that HECW2 interacts with two lamin A-binding proteins: proliferating cell nuclear antigen (PCNA), via a canonical PCNA-interacting protein (PIP) motif, and lamin B1. HECW2 mediates their ubiquitination and targets them for proteasomal degradation. | 29753763 |
| 2017-12-02 11:02:00 | HECW2, a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT-like 1 (AMOTL1) stability. | 27498087 |
| 2017-11-25 14:34:00 | HECW2 is an ubiquitin ligase that stabilises p73, a crucial mediator of neurodevelopment and neurogenesis. This study implicates pathogenic genetic variants in HECW2 as potential causes of neurodevelopmental disorders in humans. | 27389779 |
| 2017-08-26 12:04:00 | This work lends further support to previously identified candidate gene HECW2 as a novel candidate gene in intellectual disability and epilepsy. In 39 patient-parent trios, 29 de novo mutations in coding sequence were identified. | 27334371 |
| Type | IDs |
|---|---|
| Synonymous | NDHSAL, NEDL2 |
| Gene |
UniProtKB-ID:
HECW2_HUMAN,
A0A2R8Y6F3_HUMAN
UniprotKB:
Q9P2P5,
A0A2R8Y6F3
UniParc:
UPI00001A75E8,
UPI0003EB0352,
UPI000BB9FC7B
EMBL:
BC117198,
AC073905,
AC074090,
AB037722,
AC093379,
AC020571,
CR749424,
BC117194,
AC068544,
AL390186
Ensembl:
ENSG00000138411
KO:
hsa:57520
|
| Nucleutide sequences |
EMBL-CDS:
CAH18262.1,
CAB99103.1,
AAI17199.1,
AAI17195.1,
BAA92539.1
Ensembl_TRS:
ENST00000647236,
ENST00000644978,
ENST00000260983,
ENST00000644256,
ENST00000644030
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000260983,
ENSP00000494800,
ENSP00000494649,
ENSP00000495418,
ENSP00000495504
RefSeq:
NP_065811.1,
NP_001335697.1,
NP_001291769.1,
XP_024308789.1,
XP_024308788.1,
XP_006712711.1,
XP_006712709.1
|
| Others |
UniRef100:
UniRef100_A0A2R8Y6F3,
UniRef100_Q9P2P5
UniRef90:
UniRef90_Q9P2P5
UniRef50:
UniRef50_Q9P2P5
UniGene:
Hs.654742
CCDS:
CCDS33354.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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