| Type | Description |
|---|---|
| Definition | ubiquitin recognition factor in ER associated degradation 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 16:01:00 | Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative. | 33402676 |
| 2020-07-04 11:16:00 | Multisystem proteinopathy mutations in VCP/p97 increase NPLOC4-UFD1L binding and substrate processing. | 31623962 |
| 2020-03-21 11:54:00 | results support that Ufd1 S229 phosphorylation status mediated by serves as a key regulatory point for the VCP-Ufd1 interaction and functional ERAD. | 31477623 |
| 2019-06-15 11:39:00 | CHOP inactivation or BCL2 overexpression is sufficient to rescue tumor cell apoptosis induced by UFD1 knockdown. | 29743725 |
| 2018-05-12 11:36:00 | We demonstrate that WT p97 can unfold proteins and that this activity is dependent on the p97 adaptor NPLOC4-UFD1L, ATP hydrolysis, and substrate ubiquitination, with branched chains providing maximal stimulation. | 28512218 |
| Type | IDs |
|---|---|
| Synonymous | UFD1L |
| Gene |
UniProtKB-ID:
UFD1_HUMAN,
Q541A5_HUMAN
UniprotKB:
Q92890,
Q541A5
UniParc:
UPI0000137AD3,
UPI000155D5E9,
UPI0000000A0D
EMBL:
CH471176,
AY101594,
AC000068,
AK225877,
AJ239058,
BC001049,
BC005087,
AF141201,
AC000087,
U64444,
CR456607
Ensembl:
ENSG00000070010
KO:
hsa:7353
|
| Nucleutide sequences |
EMBL-CDS:
AAD28788.1,
AAD08720.1,
CAG30493.1,
AAH01049.1,
AAH05087.1,
EAX03038.1,
CAC20414.1,
AAM48288.1
Gene_ORFName:
hCG_17901
Ensembl_TRS:
ENST00000399523,
ENST00000263202
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000263202,
ENSP00000382439
RefSeq:
NP_005650.2,
NP_001030324.2,
NP_001349839.1
|
| Others |
UniRef100:
UniRef100_Q92890
UniRef90:
UniRef90_Q92890
UniRef50:
UniRef50_Q92890
UniGene:
Hs.474213
CCDS:
CCDS33600.2,
CCDS13761.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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