| Type | Description |
|---|---|
| Definition | OTU deubiquitinase 7B |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:09:00 | Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding. | 31937588 |
| 2020-05-16 11:10:00 | The present study demonstrates that linc00976 enhances the proliferation and invasion ability of PC cells by upregulating OTUD7B expression, which was a target of miR-137. Ultimately, OTUD7B mediates EGFR and MAPK signaling pathway. | 31747939 |
| 2019-12-21 10:41:00 | Cezanne serves as a "reader" of the Lys63-linkage polyubiquitin at DNA damage sites and an "eraser" of the Lys11-linkage ubiquitination, indicating a crosstalk between linkage-specific ubiquitination at DNA damage sites | 31699778 |
| 2019-05-04 12:46:00 | Cezanne binds established APC/C substrates and reverses their APC/C-mediated ubiquitination. Cezanne depletion accelerates APC/C substrate degradation and causes errors in mitotic progression and formation of micronuclei. | 29973362 |
| 2018-10-20 10:46:00 | Study demonstrated that the N-terminal UBA domain is crucial for the function of Cezanne during NF-kappaB activation. Cezanne is recognized and recruited into activated TNFR complex by specifically binding to polyubiquitinated signaling proteins after TNF stimulation through its N-terminal polyubiquitin binding site. | 28817177 |
| Type | IDs |
|---|---|
| Synonymous | CEZANNE, ZA20D1 |
| Gene |
UniProtKB-ID:
OTU7B_HUMAN
UniprotKB:
Q6GQQ9
UniParc:
UPI00020654B5,
UPI000020415D
EMBL:
AL122102,
AL590487,
BC072681,
AK299790,
AJ293573,
CH471121,
BC020622
Ensembl:
ENSG00000264522
KO:
hsa:56957
|
| Nucleutide sequences |
EMBL-CDS:
AAH20622.1,
EAW53586.1,
CAB97494.1,
CAB59268.1,
CAI12651.1,
BAH13129.1,
AAH72681.1,
EAW53587.1
Ensembl_TRS:
ENST00000581312
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000462729
RefSeq:
NP_064590.2,
XP_011508084.1,
XP_016857339.1,
XP_011508087.1,
XP_011508089.1,
XP_011508090.1,
XP_011508086.1,
XP_011508088.1,
XP_016857340.1,
XP_024304284.1
|
| Others |
UniRef100:
UniRef100_Q6GQQ9
UniRef90:
UniRef90_Q6GQQ9
UniRef50:
UniRef50_Q6GQQ9
UniGene:
Hs.98322
CCDS:
CCDS72903.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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