| Type | Description |
|---|---|
| Definition | sortilin related VPS10 domain containing receptor 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-06-08 11:32:00 | First study reporting on human subjects with a SORCS3 gene defect with infantile spasms and intellectual disability; this supports the important role of SORCS3 in the central nervous system. | 30586538 |
| 2018-01-27 10:07:00 | SORCS3 may be important in MS pathogenesis. | 26362888 |
| 2017-10-07 10:05:00 | Here the authors have characterized SorCS1, SorCS2 and SorCS3 using biochemical methods and electron microscopy. They found that their purified extracellular domains co-exist in stable dimeric and monomeric populations. | 28827148 |
| 2010-06-30 22:05:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| 2010-01-21 00:00:00 | The propeptide is not a requirement for normal processing of the receptor and does not prevent ligands from binding to the SorCS3 precursor form | 15710408 |
| Type | IDs |
|---|---|
| Synonymous | SORCS |
| Gene |
UniProtKB-ID:
SORC3_HUMAN,
Q86XB2_HUMAN
UniprotKB:
Q9UPU3,
Q86XB2
UniParc:
UPI000000DB16,
UPI0000135CE1
EMBL:
AL596118,
AL161646,
BC045754,
AB028982,
AL358949,
AL353900,
AL365449,
AL445492
Ensembl:
ENSG00000156395
KO:
hsa:22986
|
| Nucleutide sequences |
EMBL-CDS:
BAA83011.2,
AAH45754.1
Ensembl_TRS:
ENST00000369701,
ENST00000369699
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000358715,
ENSP00000358713
RefSeq:
NP_055793.1,
XP_011537844.1
|
| Others |
UniRef100:
UniRef100_Q9UPU3,
UniRef100_Q86XB2
UniRef90:
UniRef90_Q86XB2,
UniRef90_Q8VI51
UniRef50:
UniRef50_Q8WY21-4,
UniRef50_A0A2I0U594
UniGene:
Hs.671950
CCDS:
CCDS7558.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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