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1478 CSTF2

1478

CSTF2

cleavage stimulation factor subunit 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition cleavage stimulation factor subunit 2

研究结论

Date Results Publications
2020-11-21 13:13:00 A missense mutation in the CSTF2 gene that impairs the function of the RNA recognition motif and causes defects in 3' end processing is associated with intellectual disability in humans. 32816001
2019-10-12 12:34:00 CSTF2 exerts critical roles in activation of RAC1 by promoting 3'UTR shortening of RAC1 mRNAs through two transcription elongation factors, AFF1 and AFF4, in urothelial carcinoma of the bladder pathogenesis 30143523
2019-07-27 10:55:00 Reverse genetics and nuclear magnetic resonance studies of recombinant CstF-64 (RRM-Hinge) and CstF-77 (monkeytail-carboxy-terminal domain) indicate that the last 30 amino acids of CstF-77 increases the stability of the RRM, thus altering the affinity of the complex for RNA. These results provide new insights into the mechanism by which CstF regulates the location of the RNA cleavage site during Cleavage/polyadenylation. 30257008
2019-02-16 10:40:00 The findings demonstrate that constitutive Tip110 expression in human cord blood CD34(+) cells is regulated, at least in part, through its interaction with CstF64, recruitment of CstF64 to, and selective usage of two polyadenylation sites within its 3'UTR. 29583087
2017-11-04 11:11:00 hnRNP H binds to two specific G-runs in exon 5a of ACHE and activates the distal alternative 3 splice site (ss) between exons 5a and 5b. Furthermore, hnRNP H competes for binding of CstF64 to the overlapping binding sites in exon 5a, and suppresses the selection of a cryptic polyadenylation site, which additionally ensures transcription of the distal 3 ss required for the generation of AChET isoform. 28180311

名称对应

Type IDs
Synonymous CstF-64
Gene
UniProtKB-ID: CSTF2_HUMAN, B4DUD5_HUMAN, B3V096_HUMAN, E7EWR4_HUMAN
UniprotKB: P33240, B4DUD5, B3V096, E7EWR4
UniParc: UPI0001AE7000, UPI000003BCAF, UPI000178CCEC, UPI0000551C75, UPI00017A7E1D
EMBL: BC017712, Z95327, BC033135, BT009778, M85085, AK300600, EU616679, Z83819
Ensembl: ENSG00000101811
KO: hsa:1478
Nucleutide sequences
EMBL-CDS: AAH17712.1, AAP88780.1, AAH33135.1, AAA35724.1, BAG62297.1, ACF05699.1
Ensembl_TRS: ENST00000372972, ENST00000415585
Protein sequencees
Ensembl_PRO: ENSP00000362063, ENSP00000387996
RefSeq: NP_001293138.1, NP_001316.1, NP_001293135.1
Others
UniRef100: UniRef100_B3V096, UniRef100_B4DUD5, UniRef100_E7EWR4, UniRef100_P33240
UniRef90: UniRef90_P33240
UniRef50: UniRef50_P33240
UniGene: Hs.132370
CCDS: CCDS14473.1

全选

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