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1650 DDOST

1650

DDOST

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

protein-coding

Homo sapiens

基因描述

Type Description
Definition dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

研究结论

Date Results Publications
2020-04-18 10:12:00 his review summarizes our current knowledge regarding the functions of OST in the light of health and tumor progression, and discusses perspectives on the clinical relevance of inhibiting OST as a tumor treatment. 31810196
2019-07-20 12:40:00 Study using transgenic human OST48 knock-in mice demonstrated that OST48 (encoded by DDOST gene) is a facilitator of increased advanced glycation end-products (AGE) deposition in the liver and OST48-AGE pathway leads to the onset of liver injury in combination with central adiposity and glucose intolerance, despite ample physical activity. 28947796
2018-01-06 12:27:00 DDOST and SIRT1 are differently expressed in peripheral blood mononuclear cells from type 1 diabetes patients with and without microvascular complications. Their expression is also influenced by dietary advanced glycation end-products and by statins and angiotensin receptor blockers. 29027826
2017-11-25 13:19:00 the cell-cycle-dependent post-translation modification of TREX1 regulates its interaction with OST. 28297665
2012-06-23 11:59:00 Found a 22 bp deletion and a missense mutation in DDOST. 22305527

名称对应

Type IDs
Synonymous AGER1, CDG1R, GATD6, OKSWcl45, OST, OST48, WBP1
Gene
UniProtKB-ID: OST48_HUMAN, A0A024RAD5_HUMAN
UniprotKB: P39656, A0A024RAD5
UniParc: UPI000013C9E0, UPI0001AE7824, UPI0004AC3F6B, UPI0000163BD0
EMBL: AK296041, D29643, AK315633, AB062391, D89060, AL391357, CH471134, BC002594, AK297009
Ensembl: ENSG00000244038
KO: hsa:1650
Nucleutide sequences
EMBL-CDS: BAA23670.1, BAA06126.1, BAB93478.1, BAG59544.1, BAG58805.1, AAH02594.1, BAG38001.1, EAW94938.1, EAW94939.1
Gene_ORFName: OK/SW-cl.45, hCG_38871
Ensembl_TRS: ENST00000375048, ENST00000415136
Protein sequencees
Ensembl_PRO: ENSP00000364188, ENSP00000399457
RefSeq: NP_005207.3
Others
UniRef100: UniRef100_A0A024RAD5, UniRef100_P39656
UniRef90: UniRef90_P39656
UniRef50: UniRef50_P39656
UniGene: Hs.523145

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