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4176 MCM7

4176

MCM7

minichromosome maintenance complex component 7

protein-coding

Homo sapiens

基因描述

Type Description
Definition minichromosome maintenance complex component 7

研究结论

Date Results Publications
2021-03-20 13:35:00 MCM7 as a marker of postsurgical progression in non-functioning pituitary adenomas. 33524001
2019-12-28 10:53:00 In this study, we demonstrated for the first time that MCM2 among MCM2-7 except for MCM5 is specifically degraded, and that MCM2 and MCM7 are localized in the cytoplasm in senescent cells. To examine the relationship between the cytoplasmic localization of MCM proteins and cell cycle phase, the distribution of DNA content of cells showing cytoplasmic localization of MCM2 and MCM7 was examined. 31092751
2019-11-30 11:59:00 Our study confirms that MCM7 is a valuable marker for assessing the progression of pancreatic neuroendocrine tumors, especially in patients with early stage disease and without distant metastasis. 30447299
2019-08-24 12:52:00 Depletion of a second MCM (MCM7), which functions in complex with MCM2 during its canonical functions, reveals an overlapping cilia-deficiency phenotype likely unconnected to replication, although MCM7 appears to regulate a distinct subset of genes and pathways. Our data suggests that MCM2 and 7 exert a role in ciliogenesis in post-mitotic tissues. 30329080
2019-06-08 11:08:00 Here, the authors show that, in human cells, cohesin loading onto chromosomes during early S phase requires the replicative helicase MCM2-7 and the kinase DDK. Cohesin and its loader SCC2/4 (NIPBL/MAU2 in humans) associate with DDK and phosphorylated MCM2-7. 29611806

名称对应

Type IDs
Synonymous CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104
Gene
UniProtKB-ID: MCM7_HUMAN, A0A0S2Z4A5_HUMAN, C6EMX8_HUMAN
UniprotKB: P33993, A0A0S2Z4A5, C6EMX8
UniParc: UPI000002ADBC, UPI0001AE524A, UPI000016AA6B, UPI000012ED9E
EMBL: BC013375, CH236956, D28480, BC009398, D55716, AK055379, CH471091, D86748, AC073842, X74796, KU178172
Ensembl: ENSG00000166508
KO: hsa:4176
Nucleutide sequences
EMBL-CDS: BAA05839.1, AAH09398.1, BAA09534.1, BAG51508.1, EAW76598.1, EAL23856.1, AAH13375.1, EAL23855.1, CAA52803.1, EAW76599.1, ALQ33630.1, BAH84845.1
Ensembl_TRS: ENST00000621318, ENST00000343023, ENST00000303887, ENST00000354230
Protein sequencees
Ensembl_PRO: ENSP00000307288, ENSP00000483795, ENSP00000344006, ENSP00000346171
RefSeq: XP_016867706.1, XP_005250405.1, NP_001265524.1, NP_877577.1, NP_005907.3
Others
UniRef100: UniRef100_C6EMX8, UniRef100_P33993
UniRef90: UniRef90_P33993
UniRef50: UniRef50_P33993
UniGene: Hs.438720
CCDS: CCDS5684.1, CCDS5683.1

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