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9733 SART3

9733

SART3

spliceosome associated factor 3, U4/U6 recycling protein

protein-coding

Homo sapiens

基因描述

Type Description
Definition spliceosome associated factor 3, U4/U6 recycling protein

研究结论

Date Results Publications
2020-06-13 10:50:00 In vitro binding experiments revealed that the RNA-recognition motifs within the SART3 sequence are responsible for selective pre-miR-34a binding. Our results provide evidence for a significant role of SART3 in miR-34a biogenesis and cell cycle progression in non-small-cell lung cancer (NSCLC) cells. 31619517
2020-05-23 11:06:00 LASTR promotes splicing efficiency by controlling SART3 association with the U4 and U6 small nuclear ribonucleoproteins (snRNP) during spliceosome recycling. 31956895
2019-03-23 12:29:00 Study demonstrated that Tip110 contributed to the regulation of the expression of IL-8 in melanoma cells and that the expression level of Tip110 had a prognostic value for melanoma patients. 30119675
2019-02-16 10:40:00 The findings demonstrate that constitutive Tip110 expression in human cord blood CD34(+) cells is regulated, at least in part, through its interaction with CstF64, recruitment of CstF64 to, and selective usage of two polyadenylation sites within its 3'UTR. 29583087
2017-11-26 01:40:00 Data suggest that ZIP, USP39, Prp24/p100/SART3, and Prp43 associate to form complex instrumental in spliceosome assembly; ZIP regulates pre-mRNA splicing of USP39 independent of RNA binding; stable 35S tri-snRNP particles are enriched in Cajal body. (ZIP = zinc finger and G-patch domain-containing protein; USP39 = ubiquitin specific peptidase 39; Prp43 = RNA helicase Prp43) 28878014

名称对应

Type IDs
Synonymous DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb)
Gene
UniProtKB-ID: SART3_HUMAN, A0A499FI31_HUMAN
UniprotKB: Q15020, A0A499FI31
UniParc: UPI000006D72B, UPI0000072D96, UPI0000074719, UPI000189A793, UPI000387C87F
EMBL: BC032601, AB020880, BC103706, KF455716, BC093784, AF387506, KF511170, AK290209, BC111983, BC041638, AC008119, D63879, AC010206, BC143253
Ensembl: ENSG00000075856
KO: hsa:9733
Nucleutide sequences
EMBL-CDS: AAH41638.1, AAK69347.1, AAH93784.1, BAA78384.1, BAA09929.1, AAI43254.1, AAI11984.1, AAI03707.1, BAF82898.1, AAH32601.1
Ensembl_TRS: ENST00000546611, ENST00000431469, ENST00000546815, ENST00000546728, ENST00000228284
Protein sequencees
Ensembl_PRO: ENSP00000448554, ENSP00000414453, ENSP00000449386, ENSP00000449743, ENSP00000228284
RefSeq: XP_005269298.1, XP_024305052.1, NP_055521.1
Others
UniRef100: UniRef100_A0A499FI31, UniRef100_Q15020
UniRef90: UniRef90_Q15020, UniRef90_Q15020-4
UniRef50: UniRef50_Q15020
UniGene: Hs.584842
CCDS: CCDS9117.1

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