| Type | Description |
|---|---|
| Definition | serrate, RNA effector molecule |
| Date | Results | Publications |
|---|---|---|
| 2020-09-12 16:05:00 | Mapping domains of ARS2 critical for its RNA decay capacity. | 32463452 |
| 2020-08-29 12:49:00 | ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages. | 32532977 |
| 2020-07-11 12:15:00 | In the present study, the authors demonstrate that ARS2 regulates both the 3=-end processing and stability of NEAT1. | 31818879 |
| 2019-10-19 12:19:00 | Overexpression of Ars2 promoted cell proliferation and colony formation in glioblastoma cells, whereas the depletion of Ars2 inhibited cell proliferation, colony formation, and tumor growth. Knockdown of Ars2 reduced the expression levels of miR-6798-3p. | 30349053 |
| 2019-08-17 12:55:00 | Depletion of Ars2 reduced the level of miR-6734-3p by inhibiting the interaction of Ars2 with either CBC complex or Drosha, leading to p27 up-regulation-mediated G1 cell cycle arrest, and culminating in inhibition of cell proliferation and leukemogenesis in AML | 30518811 |
| Type | IDs |
|---|---|
| Synonymous | ARS2, ASR2, serrate |
| Gene |
UniProtKB-ID:
SRRT_HUMAN
UniprotKB:
Q9BXP5
UniParc:
UPI0001B30126,
UPI0000126098,
UPI000002A3FD,
UPI0000049CA2,
UPI00005DC747
EMBL:
AF312032,
BC109117,
AC011895,
AL096723,
CH471091,
BC069249,
AF082871,
BC000082,
AK296131,
AK302820,
CH236956,
AF248955
Ensembl:
ENSG00000087087
KO:
hsa:51593
|
| Nucleutide sequences |
EMBL-CDS:
AAK21006.1,
AAK21005.1,
EAL23815.1,
AAD17774.1,
AAI09118.1,
BAG64018.1,
AAH69249.1,
EAW76467.1,
AAH00082.2,
AAM00189.1,
CAB46374.2,
EAL23816.1,
BAG58876.1
Ensembl_TRS:
ENST00000614484,
ENST00000618262,
ENST00000611405,
ENST00000618411
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000480421,
ENSP00000478341,
ENSP00000481173,
ENSP00000483556
RefSeq:
XP_005250462.1,
XP_016867779.1,
NP_056992.4,
NP_001122326.1,
XP_005250464.1,
NP_001122325.1,
XP_016867780.1,
NP_001122324.1,
XP_005250465.1,
XP_024302561.1,
XP_005250463.1,
XP_024302562.1
|
| Others |
UniRef100:
UniRef100_Q9BXP5
UniRef90:
UniRef90_Q9BXP5
UniRef50:
UniRef50_Q9BXP5
UniGene:
Hs.111801
CCDS:
CCDS47667.1,
CCDS34709.1,
CCDS47665.1,
CCDS47666.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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