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10910 SUGT1

10910

SUGT1

SGT1 homolog, MIS12 kinetochore complex assembly cochaperone

protein-coding

Homo sapiens

基因描述

Type Description
Definition SGT1 homolog, MIS12 kinetochore complex assembly cochaperone

研究结论

Date Results Publications
2019-06-29 11:14:00 REVIEW: cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1 30656909
2018-06-02 10:30:00 the SGT1-HSP90 complex contributes to the E3 ligase activity of the CUL4A complex that is necessary for CENP-A ubiquitylation and CENP-A deposition at the centromere. 28816574
2017-09-16 11:57:00 Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41-mediated SGT1 degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 = ring finger protein 41; SGT1 = suppressor of G2 allele of SKP1) 28696259
2017-06-24 12:19:00 Fusion of human SGT1 (hSGT1) to NOD1 LRR significantly enhanced the solubility, and the fusion protein was stabilized by coexpression of mouse Hsp90alpha. 27591899
2016-12-17 10:11:00 Data (including data from studies using purified proteins/hepatocyte lysates) suggest eEF1A1/Sgt1a interact as multimer; D2/D3 domains of eEF1A1 and TPR domain of Sgt1 are involved in multimer formation; Sgt1 competes with viral RNA to bind to eEF1A. 26545799

名称对应

Type IDs
Synonymous SGT1
Gene
UniProtKB-ID: SGT1_HUMAN, B4DYC6_HUMAN, A8K7W3_HUMAN
UniprotKB: Q9Y2Z0, B4DYC6, A8K7W3
UniParc: UPI00015DA9F7, UPI00001CDFF4, UPI000006D6DA, UPI00017A8203
EMBL: CH471124, AK292128, AL139089, BT009798, AJ344097, BC000911, AK302363, AY321358, AY271314, AF132856
Ensembl: ENSG00000165416
KO: hsa:10910
Nucleutide sequences
EMBL-CDS: AAQ76039.1, AAP88800.1, AAQ01749.1, AAD30062.1, AAH00911.1, CAC51433.1, EAW52045.1, BAG63688.1, BAF84817.1
Ensembl_TRS: ENST00000310528, ENST00000343788
Protein sequencees
Ensembl_PRO: ENSP00000367208, ENSP00000308067
RefSeq: XP_016875856.1, XP_011533195.1, XP_016875857.1, XP_011533193.1, NP_001307760.1, NP_006695.1, XP_016875855.1, NP_001124384.1, XP_016875854.1
Others
UniRef100: UniRef100_Q9Y2Z0, UniRef100_B4DYC6, UniRef100_A8K7W3
UniRef90: UniRef90_Q2KIK0, UniRef90_W5PA50, UniRef90_Q9Y2Z0
UniRef50: UniRef50_Q9Y2Z0
UniGene: Hs.281902
CCDS: CCDS45050.1, CCDS9436.1

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