| Type | Description |
|---|---|
| Definition | hook microtubule tethering protein 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-13 11:14:00 | Study demonstrates that PTPN21 activates KIF1C by binding to the stalk region. This function does not require catalytic activity of the phosphatase, and its N-terminal FERM domain alone is sufficient to stimulate the transport of KIF1C cargoes in cells as well as increasing the landing rate of KIF1C on microtubules in vitro. The cargo adapter Hook3 binds KIF1C in the same region and activates KIF1C in a similar way. | 31217419 |
| 2017-06-03 12:10:00 | This work reveals the structural details of Hook3's interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes. | 27482052 |
| 2017-05-13 17:24:00 | Single-molecule motility assays using total internal reflection fluorescence microscopy indicate that both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and higher velocities than the previously characterized dynein activator bicaudal D2 (BICD2). | 27365401 |
| 2016-05-07 10:55:00 | results of our study identify HOOK3 as a strong candidate prognostic marker with a possible role in maintaining genomic integrity in prostate cancer, which may have potential for inclusion into clinical routine assays | 26230842 |
| 2016-03-12 10:34:00 | Results found that downregulation of Hook3 expression slows down endosomal transport and increases beta-amyloid production suggesting that Hook3 might play a critical role in pathogenic events exacerbating Alzheimer disease. | 25799409 |
| Type | IDs |
|---|---|
| Synonymous | HK3 |
| Gene |
UniProtKB-ID:
HOOK3_HUMAN
UniprotKB:
Q86VS8
UniParc:
UPI000006DD7B
EMBL:
CH471080,
AK090540,
AF241830,
BC056146,
BC048304
Ensembl:
ENSG00000168172
KO:
hsa:84376
|
| Nucleutide sequences |
EMBL-CDS:
AAH56146.1,
AAH48304.1,
EAW63197.1,
AAK29204.1,
BAC03473.1,
EAW63198.1
Ensembl_TRS:
ENST00000307602
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000305699
RefSeq:
NP_115786.1
|
| Others |
UniRef100:
UniRef100_Q86VS8
UniRef90:
UniRef90_Q86VS8
UniRef50:
UniRef50_Q86VS8
UniGene:
Hs.162852
CCDS:
CCDS6139.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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