| Type | Description |
|---|---|
| Definition | structural maintenance of chromosomes 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 10:17:00 | Study found that mRNA expression of SMC4 was upregulated in invasive breast cancer cells. Patients with high mRNA level of SMC4 suffered different survival with triple negative breast cancer (TNBC) and non-TNBC. These results suggest that SMC4 could be a good biomarker for predicting the prognosis. | 31871499 |
| 2020-04-25 11:00:00 | study demonstrated a novel HIF-1-miR-219-SMC4 regulatory pathway under hypoxic condition in hepatocellular carcinoma cells. | 31828143 |
| 2019-06-29 11:36:00 | this paper shows that condensin Smc4 promotes inflammatory innate immune response by epigenetically enhancing NEMO transcription | 29803706 |
| 2019-06-08 12:48:00 | Study examined the expression of SMC4 in acute myeloid leukemia (AML) pediatric patients cells and normal cells and revealed that SMC4 was significantly higher than control. Utilizing SMC4 gene knockdown in the established MLL-AF9 AML mouse model study found that SMC4 knockdown inhibited AML progression by maintaining leukemia stem cells. | 29043883 |
| 2016-04-23 10:26:00 | analysis of functional differences of SMC2 and SMC4 hinge domain between condensins and cohesin in DNA recognition | 26491021 |
| Type | IDs |
|---|---|
| Synonymous | CAP-C, CAPC, SMC-4, SMC4L1 |
| Gene |
UniProtKB-ID:
SMC4_HUMAN,
E9PD53_HUMAN,
B3KXX5_HUMAN,
Q58F29_HUMAN
UniprotKB:
Q9NTJ3,
E9PD53,
B3KXX5,
Q58F29
UniParc:
UPI000006DA0A,
UPI0000191DFF,
UPI0001B796ED,
UPI00004A291E,
UPI00004F6EBD
EMBL:
AL136877,
AK128143,
AB019987,
BC106033,
AL833949,
BC001557,
AF092564,
AC024221,
CH471052
Ensembl:
ENSG00000113810
KO:
hsa:10051
|
| Nucleutide sequences |
EMBL-CDS:
CAD38803.1,
AAC72361.1,
CAB66811.1,
EAW78640.1,
BAA73535.1,
EAW78639.1,
BAG54637.1,
AAI06034.1,
AAH01557.1
Ensembl_TRS:
ENST00000357388,
ENST00000462787,
ENST00000344722,
ENST00000469762
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000349961,
ENSP00000420734,
ENSP00000341382,
ENSP00000417964
RefSeq:
NP_005487.3,
NP_001275682.1,
XP_011510613.1,
NP_001002800.1,
XP_016860980.1,
XP_011510614.1,
XP_006713522.1
|
| Others |
UniRef100:
UniRef100_B3KXX5,
UniRef100_Q58F29,
UniRef100_Q9NTJ3,
UniRef100_E9PD53
UniRef90:
UniRef90_A0A2K6U2K0,
UniRef90_Q9ERA5,
UniRef90_E1BMZ9,
UniRef90_Q9NTJ3
UniRef50:
UniRef50_Q3UZJ7,
UniRef50_Q9NTJ3
UniGene:
Hs.58992
CCDS:
CCDS3189.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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