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10569 SLU7

10569

SLU7

SLU7 homolog, splicing factor

protein-coding

Homo sapiens

基因描述

Type Description
Definition SLU7 homolog, splicing factor

研究结论

Date Results Publications
2019-10-12 10:57:00 We define a molecular pathway through which SLU7 keeps in check the generation of truncated forms of the splicing factor SRSF3 (SRp20) (SRSF3-TR). Behaving as dominant negative, or by gain-of-function, SRSF3-TR impair the correct splicing and expression of the splicing regulator SRSF1 (ASF/SF2) and the crucial SCC protein sororin. 30657957
2019-07-13 12:25:00 High SLU7 expression is associated with alcoholic steatohepatitis. 29870742
2017-09-02 11:50:00 these findings indicate that SLU7 is co-opted by hepatocellular carcinoma (HCC) cells and other tumor cell types to maintain survival, and identify this splicing regulator as a new determinant for the expression of the oncogenic miR-17-92 cluster. This novel mechanism may be exploited for the development of antitumoral strategies in cancers displaying such SLU7-miR-17-92 crosstalk 26804174
2014-10-11 10:50:00 SLU7 knockdown in liver cells resulted in profound changes in pre-mRNA splicing and gene expression, leading to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern. 24865429
2013-10-26 10:52:00 These observations together point to an altered recruitment and dependence on SLU7, suggesting its role in facilitating transitions that promote catalysis, and highlight the diversity in spliceosome assembly. 23754748

名称对应

Type IDs
Synonymous 9G8, hSlu7
Gene
UniProtKB-ID: SLU7_HUMAN
UniprotKB: O95391
UniParc: UPI000013E3CE
EMBL: CH471062, DQ174517, AF101074, DQ174516, BC010634, AY486334, AC091842
Ensembl: ENSG00000164609
KO: hsa:10569
Nucleutide sequences
EMBL-CDS: ABA08382.1, AAS59410.1, AAD13774.1, ABA08383.1, EAW61554.1, EAW61555.1, AAH10634.1
Ensembl_TRS: ENST00000297151
Protein sequencees
Ensembl_PRO: ENSP00000297151
RefSeq: NP_001351451.1, NP_006416.3, NP_001351452.1, XP_024310095.1, NP_001351450.1, NP_001351449.1, NP_001351447.1, NP_001351446.1
Others
UniRef100: UniRef100_O95391
UniRef90: UniRef90_O95391
UniRef50: UniRef50_O95391
UniGene: Hs.435342
CCDS: CCDS4352.1

全选

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