| Type | Description |
|---|---|
| Definition | exocyst complex component 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-09-14 11:02:00 | Sec6 increased the phosphorylation of p38 MAPK through the activation of MAPK kinase 3/6 (MKK3/6). Moreover, Sec6 knockdown suppressed the phosphorylation of HSP27 at Ser(78) and Ser(82) sites via suppression of activated MK2. | 29729335 |
| 2016-12-17 10:11:00 | Sec6 regulate Bcl-2 and Mcl-1 expressions but not Bcl-xl in malignant peripheral nerve sheath tumor cells. | 26892009 |
| 2016-03-26 10:36:00 | Sec6 regulates NF-kappaB transcriptional activity via the control of the phosphorylation of IkappaBalpha, p90RSK1, and ERK | 26247921 |
| 2016-01-16 11:36:00 | The study explores the role of the exocyst complex component Sec6/8 in genomic stability. | 26283729 |
| 2015-09-05 11:11:00 | Sec6 regulates cytoplasmic translocation of p27 through p27 phosphorylation at Thr157, thereby promoting p27 degradation in the cytoplasm via interaction with Jab1 and Siah1 and suppressing cell cycle progression. | 24949832 |
| Type | IDs |
|---|---|
| Synonymous | SEC6, SEC6L1, Sec6p |
| Gene |
UniProtKB-ID:
EXOC3_HUMAN,
Q69YP2_HUMAN,
A0A024QYZ6_HUMAN
UniprotKB:
O60645,
Q69YP2,
A0A024QYZ6
UniParc:
UPI000004A021,
UPI0000373DB7
EMBL:
CH471235,
AC010442,
GU727644,
AK074086,
BC019304,
AF055006,
AL832434,
BC001511,
BC064569
Ensembl:
ENSG00000180104
KO:
hsa:11336
|
| Nucleutide sequences |
EMBL-CDS:
AAC09358.1,
AAH01511.2,
BAB84912.1,
ADU87645.1,
AAH64569.1,
AAH19304.1,
EAW51000.1,
CAH10613.1,
EAW51003.1,
EAW51002.1
Gene_ORFName:
hCG_17068
Ensembl_TRS:
ENST00000512944,
ENST00000315013
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000323377,
ENSP00000425587
RefSeq:
NP_009208.2
|
| Others |
UniRef100:
UniRef100_O60645
UniRef90:
UniRef90_O60645
UniRef50:
UniRef50_O60645
UniGene:
Hs.481464
CCDS:
CCDS54830.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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