| Type | Description |
|---|---|
| Definition | spermine synthase |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:27:00 | Whole-exome sequencing identifies a novel mutation in spermine synthase gene (SMS) associated with Snyder-Robinson Syndrome. | 32838743 |
| 2020-09-05 13:58:00 | Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression. | 32591507 |
| 2020-02-22 10:06:00 | Spermine synthase (SMS) localized together with myosin Va (MyoVa) in cytoplasmic vesicles of breast cancer MCF-7 and neuroblastoma SH-SY5Y cell lines, known to produce exosomes, supporting a role for MyoVa in SMS expression and targeting. | 30733278 |
| 2016-10-22 11:19:00 | Missense mutations causing Snyder-Robinson Syndrome resulting in dysfunctional spermine synthase cause the destabilization of the protein. | 26761001 |
| 2014-03-22 10:23:00 | Results show that p.Y328C, a missense mutation in SMS is responsible for the patients having a mild form of Snyder-Robinson syndrome. | 23696453 |
| Type | IDs |
|---|---|
| Synonymous | MRSR, SPMSY, SRS, SpS |
| Gene |
UniProtKB-ID:
SPSY_HUMAN
UniprotKB:
P52788
UniParc:
UPI0000135E88,
UPI000059DAD6
EMBL:
AD001528,
AK313834,
U53331,
CH471074,
BC009898,
BC085621,
Z49099,
U73023
Ensembl:
ENSG00000102172
KO:
hsa:6611
|
| Nucleutide sequences |
EMBL-CDS:
AAH09898.1,
EAW98984.1,
BAG36567.1,
AAH85621.1,
AAB61308.1,
CAA88921.1,
AAD08634.1
Ensembl_TRS:
ENST00000379404,
ENST00000404933
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000385746,
ENSP00000368714
RefSeq:
XP_016885243.1,
XP_016885244.1,
XP_024308195.1,
NP_001245352.1,
XP_005274639.1,
XP_016885242.1,
XP_011543870.1,
NP_004586.2
|
| Others |
UniRef100:
UniRef100_P52788
UniRef90:
UniRef90_P52788
UniRef50:
UniRef50_P52788
UniGene:
Hs.724874
CCDS:
CCDS14203.1,
CCDS59161.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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