| Type | Description |
|---|---|
| Definition | cordon-bleu WH2 repeat protein |
| Date | Results | Publications |
|---|---|---|
| 2018-01-20 11:48:00 | Data show that six patients had large interstitial deletions starting within intronic regions of COBL at diagnosis, which is ~611 Kb downstream of IKZF1, suggesting that COBL is a hotspot for IKZF1 deletion (DeltaIKZF1). | 27419633 |
| 2017-12-09 12:05:00 | Two single-nucleotide polymorphisms at novel loci, rs112404845 (P = 3.8 x 10-8), upstream of COBL, and rs16961023 (P = 4.6 x 10-8), downstream of SLC10A2, obtained genome-wide significant evidence of association with the posterior liability of late-onset Alzheimer's disease in African Americans. | 27770636 |
| 2016-04-23 10:54:00 | Ca2+/Calmodulin modulates Cobl's actin binding properties and furthermore promotes Cobl's previously identified interactions with the membrane-shaping F-BAR protein syndapin I, which accumulated with Cobl at nascent dendritic protrusion sites. | 26334624 |
| 2014-11-22 13:37:00 | Filament severing displayed the greatest stringency and was abolished in all mutated forms of Cobl-KAB. | 24415668 |
| 2011-10-15 10:53:00 | Cordon-Bleu works as a dynamizer of actin assembly by combining many properties of profilin with weak filament nucleating and powerful filament severing activities and sequestration of ADP-actin, which generate oscillatory polymerization kinetics. | 21816349 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
COBL_HUMAN
UniprotKB:
O75128
UniParc:
UPI0001F992C2,
UPI0000E8259E,
UPI00001A9480,
UPI0000E8259D,
UPI0001F992C3,
UPI000050D01C,
UPI000067CA61
EMBL:
AC012372,
AB014533,
CH471128,
AC005535,
BC045771,
BC094695,
BC144099,
CH236955,
BC136441,
BC029275,
AC004414,
AL713786,
BC111496,
BC150263
Ensembl:
ENSG00000106078
KO:
hsa:23242
|
| Nucleutide sequences |
EMBL-CDS:
BAA31608.1,
AAI11497.1,
CAD28543.1,
AAH94695.1,
AAI36442.1,
EAW60962.1,
AAH45771.1,
AAI44100.1,
AAH29275.1,
AAI50264.1,
EAL23896.1
Ensembl_TRS:
ENST00000441453,
ENST00000395542,
ENST00000395540,
ENST00000265136
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000399500,
ENSP00000378912,
ENSP00000378910,
ENSP00000265136
RefSeq:
XP_011513538.1,
XP_011513542.1,
XP_011513539.1,
NP_001333371.1,
NP_001333373.1,
XP_011513540.1,
NP_056013.2,
XP_016867387.1,
NP_001333372.1,
XP_011513543.1,
XP_011513536.1,
XP_005271807.1,
XP_011513537.1,
NP_001333370.1,
XP_005271808.1,
NP_001274365.1,
XP_011513541.1,
NP_001274367.1
|
| Others |
UniRef100:
UniRef100_O75128
UniRef90:
UniRef90_O75128
UniRef50:
UniRef50_Q5NBX1
UniGene:
Hs.99141
CCDS:
CCDS87505.1,
CCDS75601.1,
CCDS75602.1,
CCDS34637.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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