| Type | Description |
|---|---|
| Definition | spindle apparatus coiled-coil protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:27:00 | [Expression and clinical significance of Spindly and Bub3 in oral squamous cell carcinoma]. | 33543222 |
| 2020-04-25 12:43:00 | SPDL1 knockdown in human CRC cells significantly increased invasion and migration of tumor cells. Lower SPDL1 expression levels are significantly associated with reduced survival in CRC patients. SPDL1 depletion in human CRC cells significantly increases tumor development in xenograft assays. SPDL1 is a human CRC tumor-suppressor genes that acts downstream of MRTFB to regulate CRC growth and survival. | 31690663 |
| 2019-11-30 10:04:00 | Using mass spectrometry this study identified CCDC99 as a new target of USP45. The data showed that CCDC99 and USP45 are part of the same complex and that their interaction specifically depends on the catalytic activity of USP45. | 30258100 |
| 2016-02-13 11:38:00 | Farnesylation of Spindly is essential for its localization, & thus for proper localization of dynein & dynactin, to prometaphase kinetochores. Both Spindly and CENP-E farnesylation are required for efficient chromosome congression | 25808490 |
| 2015-06-20 12:15:00 | hSpindly is farnesylated in vivo and farnesylation is essential for its interaction with the RZZ complex and hence Kinetochore localization. | 25825516 |
| Type | IDs |
|---|---|
| Synonymous | CCDC99 |
| Gene |
UniProtKB-ID:
SPDLY_HUMAN
UniprotKB:
Q96EA4
UniParc:
UPI0001AE743C,
UPI00017A88B2,
UPI000013D5F0
EMBL:
AK304623,
AC008680,
AY517557,
AK074227,
AF269167,
AK000371,
BC012568
Ensembl:
ENSG00000040275
KO:
hsa:54908
|
| Nucleutide sequences |
EMBL-CDS:
BAA91119.1,
AAH12568.1,
AAG01408.1,
BAB85022.1,
BAG65405.1,
AAT44530.1
Ensembl_TRS:
ENST00000265295
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000265295
RefSeq:
XP_011532891.1,
XP_011532890.1,
NP_060255.3,
NP_001316568.1,
XP_011532889.1,
NP_001316572.1,
NP_001316571.1,
NP_001316569.1,
NP_001316570.1
|
| Others |
UniRef100:
UniRef100_Q96EA4
UniRef90:
UniRef90_Q96EA4
UniRef50:
UniRef50_Q96EA4
UniGene:
Hs.368710
CCDS:
CCDS4370.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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