| Type | Description |
|---|---|
| Definition | NPC intracellular cholesterol transporter 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 12:59:00 | Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. | 32544384 |
| 2020-10-31 13:13:00 | New variant associated with Niemann-Pick disease type C: Neurological manifestations and biochemical, molecular, and cellular characterisation.", trans "Nueva variante asociada a enfermedad de Niemann-Pick tipo C: manifestaciones neurologicas y caracterizacion bioquimica, molecular y celular. | 28865947 |
| 2020-05-09 13:40:00 | conclude that NPC2's affinity for all sterols is energetically favored over their self-aggregation in the lysosomal lumen. Lysosomal export of 25-OH-Chol is not strictly dependent on the NPC2 protein. | 31521631 |
| 2020-04-11 10:05:00 | The authors demonstrate that lysobisphosphatidic acid enrichment in human NPC2-deficient cells, either directly or via its biosynthetic precursor phosphtidylglycerol (PG), is entirely ineffective, indicating an obligate functional interaction between NPC2 and lysobisphosphatidic acid in cholesterol trafficking. | 31580258 |
| 2019-01-12 12:03:00 | Data show that nuclear factor kappa B subunit 2 (NF-kappaB2) regulates intracellular cholesterol transport by controlling Niemann Pick type C2 protein (NPC2) expression. | 30091016 |
| Type | IDs |
|---|---|
| Synonymous | EDDM1, HE1 |
| Gene |
UniProtKB-ID:
NPC2_HUMAN,
A0A024R6C0_HUMAN
UniprotKB:
P61916,
A0A024R6C0
UniParc:
UPI00017A7BCF,
UPI0000062218
EMBL:
BC002532,
GQ891542,
GQ891387,
CH471061,
AK298975,
X67698,
AC005479
Ensembl:
ENSG00000119655
KO:
hsa:10577
|
| Nucleutide sequences |
EMBL-CDS:
AAH02532.1,
CAA47928.1,
BAG61069.1,
ADO22404.1,
EAW81176.1,
ADO22249.1,
EAW81177.1
Gene_ORFName:
hCG_21712
Ensembl_TRS:
ENST00000541064,
ENST00000555619
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000451112,
ENSP00000442488
RefSeq:
NP_001362369.1,
NP_001350617.1,
NP_006423.1
|
| Others |
UniRef100:
UniRef100_P61916
UniRef90:
UniRef90_P61916
UniRef50:
UniRef50_P61916
UniGene:
Hs.433222
CCDS:
CCDS32121.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员