| Type | Description |
|---|---|
| Definition | tousled like kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-29 10:58:00 | Study shows that TLK2 expression is increased in glioblastoma. Furthermore, TLK2 overexpression resulted in tumor growth and metastasis via SRC signaling pathway. | 30207834 |
| 2018-12-22 12:30:00 | haploinsufficiency of TLK2 is the most likely underlying disease mechanism, leading to a consistent neurodevelopmental phenotype. | 29861108 |
| 2018-12-22 10:09:00 | Molecular basis of TLK2 activation and inhibition has been dissected. | 29955062 |
| 2018-09-29 10:11:00 | TLK2 is amplified in aggressive luminal breast neoplasms | 27694828 |
| 2017-08-19 11:58:00 | Tlk2 promotes Asf1A function during the DNA damage response in G2 to allow for proper restoration of chromatin structure at the break site and subsequent recovery from the arrest. | 26931568 |
| Type | IDs |
|---|---|
| Synonymous | HsHPK, MRD57, PKU-ALPHA |
| Gene |
UniProtKB-ID:
TLK2_HUMAN,
J3QLK5_HUMAN,
B4DUC2_HUMAN
UniprotKB:
Q86UE8,
J3QLK5,
B4DUC2
UniParc:
UPI00017A7DED,
UPI00001B6B0F,
UPI00001B6B10,
UPI00001B6B0E,
UPI000268B2E5
EMBL:
CH471109,
AF162667,
AC008026,
AK300586,
BC044925,
AB004884,
AC080038
Ensembl:
ENSG00000146872
KO:
hsa:11011
|
| Nucleutide sequences |
EMBL-CDS:
BAA20561.1,
EAW94346.1,
EAW94348.1,
AAF03095.1,
AAH44925.2,
BAG62284.1
Ensembl_TRS:
ENST00000343388,
ENST00000326270,
ENST00000346027,
ENST00000582809
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000316512,
ENSP00000275780,
ENSP00000340800,
ENSP00000463595
RefSeq:
XP_016879533.1,
XP_011522528.1,
XP_011522523.1,
XP_011522530.1,
XP_011522533.1,
NP_001362200.1,
XP_011522518.1,
XP_011522526.1,
XP_011522524.1,
XP_011522520.1,
XP_011522531.1,
XP_011522529.1,
XP_024306320.1,
XP_016879545.1,
NP_006843.2,
XP_024306321.1,
XP_011522519.1,
NP_001362199.1,
XP_011522522.1,
XP_016879539.1,
NP_001362202.1,
XP_011522527.1,
XP_016879542.1,
XP_016879544.1,
NP_001271292.1,
XP_016879538.1,
XP_016879546.1,
NP_001271262.1,
NP_001317347.1,
XP_016879540.1,
NP_001362198.1,
XP_011522517.1,
XP_016879549.1,
XP_011522525.1,
NP_001362201.1,
XP_016879537.1,
XP_016879543.1
|
| Others |
UniRef100:
UniRef100_J3QLK5,
UniRef100_B4DUC2,
UniRef100_Q86UE8
UniRef90:
UniRef90_Q86UE8-2,
UniRef90_Q86UE8
UniRef50:
UniRef50_Q86UE8-2,
UniRef50_Q86UE8
UniGene:
Hs.445078
CCDS:
CCDS11633.1,
CCDS45753.1,
CCDS62283.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员