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8266 UBL4A

8266

UBL4A

ubiquitin like 4A

protein-coding

Homo sapiens

基因描述

Type Description
Definition ubiquitin like 4A

研究结论

Date Results Publications
2020-05-23 10:42:00 a novel positive feedback regulation of UBL4A in innate immune response combating virus invasion by enhancing the K63-linked ubiquitination of TRAF6. 31451677
2019-12-21 12:01:00 UBL4A is a novel autophagy inhibitor and tumor suppressor in PDAC. Mechanistically, UBL4A is involved in late stage autophagy, particularly in lysosomal dysfunction, causing impaired degradation of autophagosomes. 31288830
2019-01-19 11:02:00 The single point mutation of an aspartic acid to alanine (D122A) in the Ubl4A C-terminus abolishes its ability to bind the Arp2/3 complex. This mutation also destabilizes Ubl4A proteins susceptible to protease degradation. Importantly, ectopic expression of wild-type Ubl4A can induce cell death in colon cancer cells, but such pro-death activity is diminished in the D122A mutant. 30146258
2016-02-13 10:26:00 The authors identify USP13 as a gp78-associated deubiquitinase that eliminates ubiquitin conjugates from Ubl4A to maintain the functionality of Bag6. 24424410
2015-07-25 10:58:00 Data show that molecular chaperone BAG6_ubiquitin-like domain (UBL) and ubiquitin-like 4A UBL4A_UBL compete for the same binding site on N-terminal dimerisation domain of SGTA protein (SGTA_NT). 25415308

名称对应

Type IDs
Synonymous DX254E, DXS254E, G6PD, GDX, GET5, MDY2, TMA24, UBL4
Gene
UniProtKB-ID: UBL4A_HUMAN
UniprotKB: P11441
UniParc: UPI00001379D0
EMBL: BX664739, CH471172, L44140, BC043346, J03589, BC053589
Ensembl: ENSG00000102178
KO: hsa:8266
Nucleutide sequences
EMBL-CDS: AAH53589.1, AAH43346.1, AAA92650.1, AAA36790.1, EAW72700.1
Ensembl_TRS: ENST00000369660
Protein sequencees
Ensembl_PRO: ENSP00000358674
RefSeq: NP_055050.1
Others
UniRef100: UniRef100_P11441
UniRef90: UniRef90_P11441
UniRef50: UniRef50_P11441
UniGene: Hs.76480
CCDS: CCDS14754.1

全选

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