| Type | Description |
|---|---|
| Definition | NEDD8 activating enzyme E1 subunit 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-21 11:42:00 | NAE1 expression was readily detectable in Uveal Melanoma. Inhibition of the neddylation pathway by MLN4924 repressed the cancer stem-like cells properties in Uveal Melanoma | 29233905 |
| 2019-08-17 10:51:00 | it was demonstrated that high expression of neddylation components, neural precursor cell expressed, developmentally downregulated 8 (NEDD8) and NEDD8activating enzyme 1 (NAE1), were associated with poor survival of patients with hepatocellular carcinoma (HCC) | 31002342 |
| 2018-03-24 11:10:00 | Here we report that high expression of neddylation components, NEDD8 and NAE1, are associated with poor survival of Pancreatic ductal adenocarcinoma patients. Blockage of neddylation by MLN4924 significantly sensitizes pancreatic cancer cells to gemcitabine, reduced clonogenic survival, decreased invasion capacity, increased apoptosis and senescence | 28535453 |
| 2015-08-08 10:35:00 | E1 (NAE1 and UBA3) and E2 (UBC12) enzymes, as well as global NEDD8 conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma | 25229838 |
| 2013-05-25 10:32:00 | analysis of a metal-based inhibitor of NEDD8-activating enzyme | 23185368 |
| Type | IDs |
|---|---|
| Synonymous | A-116A10.1, APPBP1, HPP1, ula-1 |
| Gene |
UniProtKB-ID:
ULA1_HUMAN
UniprotKB:
Q13564
UniParc:
UPI000006EBDC,
UPI0000519471,
UPI0000519472,
UPI000059D39C
EMBL:
AY197612,
AK097680,
AC044802,
AK298159,
AK312784,
BC000480,
BC013301,
CH471092,
AL136798,
U50939,
AC004638
Ensembl:
ENSG00000159593
KO:
hsa:8883
|
| Nucleutide sequences |
EMBL-CDS:
BAH12735.1,
BAG35647.1,
CAB66732.1,
AAC50477.1,
AAC23784.1,
AAP35030.1,
AAH00480.1,
AAH13301.1,
EAW83042.1,
BAG53511.1
Gene_ORFName:
HPP1
Ensembl_TRS:
ENST00000290810,
ENST00000359087,
ENST00000394074,
ENST00000379463
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000368776,
ENSP00000351990,
ENSP00000377637,
ENSP00000290810
RefSeq:
NP_001018170.1,
NP_001273429.1,
XP_005256272.1,
NP_001018169.1,
NP_003896.1
|
| Others |
UniRef100:
UniRef100_Q13564
UniRef90:
UniRef90_Q13564
UniRef50:
UniRef50_Q13564
UniGene:
Hs.460978
CCDS:
CCDS42172.1,
CCDS42171.1,
CCDS10820.1,
CCDS67050.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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