| Type | Description |
|---|---|
| Definition | tubulin beta 1 class VI |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 13:05:00 | Author found that the nuclear accumulation of p53 (also termed TP53) and the expression of pro-apoptotic genes triggered by genotoxic stress were blocked in TUBB1-deficient cells and, accordingly, apoptosis after DNA damage was diminished by knockdown of TUBB1. | 30854628 |
| 2019-11-16 12:36:00 | novel mutation is detected in the exon of the TUBB1 gene in children with hypothyroidism and thyroid dysgenesis in Shandong | 31642429 |
| 2019-07-27 12:15:00 | TUBB1 mutations caused the formation of macroplatelets and hyperaggregation of human platelets after stimulation by low doses of agonists. | 30446499 |
| 2019-04-20 10:13:00 | A novel mutation (c.1267C>T nonsense mutation (p.Q423*)) located in the C-terminal part of the beta1-tubulin protein is reported, confirming that this domain plays a key role in microtubule assembly. | 27905099 |
| 2018-08-11 10:11:00 | Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion. | 29044293 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
TBB1_HUMAN
UniprotKB:
Q9H4B7
UniParc:
UPI0000071B14
EMBL:
AL109840,
BC033679,
AJ292757
Ensembl:
ENSG00000101162
KO:
hsa:81027
|
| Nucleutide sequences |
EMBL-CDS:
AAH33679.1,
CAC16605.1
Ensembl_TRS:
ENST00000217133
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000217133
RefSeq:
XP_016883574.1,
NP_110400.1
|
| Others |
UniRef100:
UniRef100_Q9H4B7
UniRef90:
UniRef90_Q9H4B7
UniRef50:
UniRef50_Q9H4B7
UniGene:
Hs.303023
CCDS:
CCDS13475.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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