| Type | Description |
|---|---|
| Definition | mitofusin 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:28:00 | The GDP-Bound State of Mitochondrial Mfn1 Induces Membrane Adhesion of Apposing Lipid Vesicles through a Cooperative Binding Mechanism. | 32708307 |
| 2021-01-16 15:59:00 | Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth. | 31947947 |
| 2020-07-18 11:56:00 | Our results reveal a critical involvement of mitochondrial dynamics in hepatocellular carcinoma (HCC) metastasis via modulating glucose metabolic reprogramming. MFN1 may serve as a novel potential therapeutic target for HCC | 31819189 |
| 2020-06-06 12:14:00 | This study elucidates an essential role of MFN1 in stem cell fate determination to mediate EMT-associated stemness. | 30527740 |
| 2019-11-09 11:58:00 | Human Mfn1 contains internal N-Terminal mitochondrial targeting sequence (MTS) localized in the loop region between the two helices of the conserved transmembrane domain. Internal MTS is a shared feature of all opisthokont mitofusins. It facilitates anchoring and targeting of these proteins to the mitochondrial membrane. | 30635120 |
| Type | IDs |
|---|---|
| Synonymous | hfzo1, hfzo2 |
| Gene |
UniProtKB-ID:
MFN1_HUMAN
UniprotKB:
Q8IWA4
UniParc:
UPI0000367818,
UPI000034ECDB,
UPI0000074528
EMBL:
AK000700,
AC007620,
U95822,
AC007823,
AF054986,
KF457722,
AK314306,
CH471052,
BC040557,
AF329637
Ensembl:
ENSG00000171109
KO:
hsa:55669
|
| Nucleutide sequences |
EMBL-CDS:
EAW78410.1,
AAB64220.1,
BAA91327.1,
AAK06840.1,
EAW78411.1,
AAC09347.1,
EAW78406.1,
AAH40557.1,
BAG36958.1
Ensembl_TRS:
ENST00000357390,
ENST00000471841,
ENST00000263969
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000420617,
ENSP00000349963,
ENSP00000263969
RefSeq:
XP_011511265.1,
NP_284941.2,
XP_005247653.2
|
| Others |
UniRef100:
UniRef100_Q8IWA4
UniRef90:
UniRef90_Q8IWA4
UniRef50:
UniRef50_Q8IWA4
UniGene:
Hs.478383
CCDS:
CCDS3228.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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