| Type | Description |
|---|---|
| Definition | serine hydroxymethyltransferase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-14 11:30:00 | The human cytosolic serine hydroxymethyltransferase /Deltaflap variant exhibited different catalytic properties in (6S)-tetrahydrofolate (THF)-dependent reactions compared with the WT but had similar activity in THF-independent aldol cleavage of beta-hydroxyamino acid. | 31118236 |
| 2020-01-25 14:01:00 | association of the variant rs1979277 (G > A) and nonsyndromic cleft lip with or without cleft palate in a Chilean population | 31713293 |
| 2019-11-30 12:03:00 | The moonlighting RNA-binding activity of cytosolic SHMT contributes to control compartmentalization of serine metabolism. | 30809670 |
| 2019-08-03 13:04:00 | Characterized the serine hydroxymethyltransferase reaction catalyzed by SHMT1 and SHMT2, with a focus on pH dependence and substrate inhibition. SHMT2 maintains a pronounced tetrahydrofolate substrate inhibition even at the alkaline pH characteristic of the mitochondrial matrix, whereas with SHMT1 this is almost abolished. At this pH, SHMT2 also shows a catalytic efficiency that is much higher than that of SHMT1. | 30500180 |
| 2019-07-20 12:16:00 | miR-218-5p suppresses the killing effect of natural killer cells to lung adenocarcinoma cells by targeting SHMT1. | 31124332 |
| Type | IDs |
|---|---|
| Synonymous | CSHMT, SHMT |
| Gene |
UniProtKB-ID:
GLYC_HUMAN
UniprotKB:
P34896
UniParc:
UPI000002AA9C,
UPI00017A769A,
UPI000002AA9D,
UPI0000001C71
EMBL:
AK298415,
BC022874,
BC038598,
L23928,
CH471196,
Y14485,
Y14487,
AL353997,
Y14486,
L11931,
AC127537,
BC007979
Ensembl:
ENSG00000284320,
ENSG00000176974
KO:
hsa:6470
|
| Nucleutide sequences |
EMBL-CDS:
CAB54839.1,
AAA36019.1,
CAB54840.1,
AAH38598.1,
AAA36018.1,
BAG60641.1,
EAW55641.1,
EAW55640.1,
EAW55637.1,
AAA63257.1,
CAB54838.1,
AAA36020.1,
AAH22874.1,
AAH07979.1
Ensembl_TRS:
ENST00000354098,
ENST00000316694,
ENST00000640392,
ENST00000644141,
ENST00000352886
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000492715,
ENSP00000345881,
ENSP00000318805,
ENSP00000495756,
ENSP00000318868
RefSeq:
XP_016880447.1,
NP_004160.3,
XP_024306657.1,
XP_024306656.1,
NP_001268715.1,
XP_016880446.1,
NP_683718.1,
XP_005256824.1,
XP_024306655.1,
XP_024306658.1,
XP_011522294.1
|
| Others |
UniRef100:
UniRef100_P34896
UniRef90:
UniRef90_P34896
UniRef50:
UniRef50_P34896
UniGene:
Hs.513987,
Hs.592944,
Hs.636044
CCDS:
CCDS11196.1,
CCDS11197.1,
CCDS62112.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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