| Type | Description |
|---|---|
| Definition | DnaJ heat shock protein family (Hsp40) member B12 |
| Date | Results | Publications |
|---|---|---|
| 2017-10-07 11:02:00 | ER-located J-protein chaperones were identified as key regulators for the iogenesis and physiological function of ERG K+ channels. They regulate two distinct aspects of K+ channel biogenesis, the stabilization and assembly of channel subunits. | 27916661 |
| 2017-08-05 10:32:00 | Data suggest that endoplasmic reticulum (ER) stress-induced apoptosis in hepatoma cells is regulated by highly labile and ER-associated BCL-2 family member BOK, which is controlled at level of protein stability by ER-associated degradation components; DNAJB12 is required in hepatoma cells to maintain BOK at low levels and suppress ER stress. (DNAJB12 = DnaJ (Hsp40) homolog, subfamily B, member 12) | 28536268 |
| 2015-01-17 13:12:00 | Over-expression of DNAJB12 or DNAJB14 causes the formation of elaborate membranous structures within cell nuclei, designated DJANGOS for DNAJ-associated nuclear globular structures. | 24732912 |
| 2011-07-09 11:59:00 | JB12 cooperates with cytosolic Hsc70 and the ubiquitin ligase RMA1 to target CFTR and CFTRDeltaF508 for degradation. | 21148293 |
| 2011-03-19 11:00:00 | DNAJB12 is a novel mammalian ER-localized J-protein that plays a vital role in the quality control of membrane proteins | 21150129 |
| Type | IDs |
|---|---|
| Synonymous | DJ10 |
| Gene |
UniProtKB-ID:
DJB12_HUMAN,
J3KPS0_HUMAN
UniprotKB:
Q9NXW2,
J3KPS0
UniParc:
UPI0000049FCE,
UPI000DF0D632,
UPI0000E592BF
EMBL:
AK000034,
AK025942,
BC011812,
BC064920,
AC091769,
AK302071,
CH471083
Ensembl:
ENSG00000148719
KO:
hsa:54788
|
| Nucleutide sequences |
EMBL-CDS:
BAA90896.1,
BAH13619.1,
AAH11812.2,
BAB15289.1,
AAH64920.1,
EAW54456.1
Gene_ORFName:
hCG_2024622
Ensembl_TRS:
ENST00000444643,
ENST00000394903,
ENST00000338820
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000403313,
ENSP00000345575,
ENSP00000378363
RefSeq:
NP_060096.4,
NP_001002762.3,
NP_001352010.1,
NP_001352009.1
|
| Others |
UniRef100:
UniRef100_Q9NXW2
UniRef90:
UniRef90_Q9NXW2
UniRef50:
UniRef50_Q9NXW2
UniGene:
Hs.500013
CCDS:
CCDS7316.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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