| Type | Description |
|---|---|
| Definition | ECSIT signalling integrator |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:30:00 | CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1. | 31620128 |
| 2019-05-11 12:55:00 | We added thalidomide to the conventional dexamethasone-containing therapy regimen for two patients with HPS who expressed ECSIT-V140A, and we observed reversal of their HPS and disease-free survival for longer than 3 years. These findings provide mechanistic insights and a potential therapeutic strategy for extranodal natural killer/T cell lymphoma-associated Hemophagocytic syndrome. | 29291352 |
| 2015-12-26 10:58:00 | mediates virus-triggered type I IFN induction by bridging RIG-I and MDA5 to the VISA complex | 25228397 |
| 2015-08-22 10:06:00 | Ubiquitination of ECSIT might have a role in the regulation of NF-kappaB activity in TLR4 signaling. | 25355951 |
| 2015-07-25 10:27:00 | Authors conclude that ECSIT appears to be a novel Hepatitis B virus X protein-interacting signal molecule and their interaction is mechanistically important in IL-1beta induction of NF-kappaB activation. | 25449573 |
| Type | IDs |
|---|---|
| Synonymous | SITPEC |
| Gene |
UniProtKB-ID:
ECSIT_HUMAN
UniprotKB:
Q9BQ95
UniParc:
UPI000187F6B5,
UPI00021BBA09,
UPI000006E5B9,
UPI0000072F31
EMBL:
BC000193,
CR457204,
BC005119,
BC008279,
AK314905,
AC008481,
AF243044
Ensembl:
ENSG00000130159
KO:
hsa:51295
|
| Nucleutide sequences |
EMBL-CDS:
AAH05119.1,
AAH08279.1,
AAF62100.1,
CAG33485.1,
AAH00193.1
Ensembl_TRS:
ENST00000270517,
ENST00000417981,
ENST00000252440,
ENST00000591104
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000466559,
ENSP00000412712,
ENSP00000252440,
ENSP00000270517
RefSeq:
NP_001135936.1,
NP_057665.2,
NP_001230133.1,
NP_001135937.1
|
| Others |
UniRef100:
UniRef100_Q9BQ95
UniRef90:
UniRef90_Q9BQ95
UniRef50:
UniRef50_Q9BQ95
UniGene:
Hs.515146
CCDS:
CCDS45980.1,
CCDS59353.1,
CCDS45979.1,
CCDS12262.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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