| Type | Description |
|---|---|
| Definition | UPF2 regulator of nonsense mediated mRNA decay |
| Date | Results | Publications |
|---|---|---|
| 2020-03-28 10:44:00 | our findings indicate that impaired UPF2-dependent nonsense-mediated decay leads to neurodevelopmental dysfunction | 31585809 |
| 2020-03-14 10:50:00 | UPF2 acts as an adaptor between Stau1 and UPF1, stimulates the catalytic activity of UPF1 and plays a central role in the formation of an Staufen-mediated mRNA decay-competent mRNP. | 31699982 |
| 2016-07-30 11:44:00 | we find that the interaction of UPF2 with UPF3b interferes with the assembly of the UPF2-eRF3 complex, and that UPF2 binds UPF3b more strongly than eRF3 | 26740584 |
| 2015-04-04 12:16:00 | UPF2 binds the FRB domain of SMG1, a region that regulates the related mTOR kinase. | 25002321 |
| 2014-08-23 11:32:00 | This study demonstrated the quantitative regulation of Upf1 and Upf2 proteins by ubiquitin-proteasome system and SMG1. | 24173962 |
| Type | IDs |
|---|---|
| Synonymous | HUPF2, RENT2, smg-3 |
| Gene |
UniProtKB-ID:
RENT2_HUMAN
UniprotKB:
Q9HAU5
UniParc:
UPI0000070D5E
EMBL:
AF301013,
BC115737,
AK000764,
CH471072,
AY013249,
AL138898,
AK096191,
AB037829,
BC114964,
AF318574,
AL080198,
AL645617,
AC073160
Ensembl:
ENSG00000151461
KO:
hsa:26019
|
| Nucleutide sequences |
EMBL-CDS:
AAG33225.1,
CAB45771.1,
EAW86330.1,
EAW86329.1,
AAI14965.1,
AAG48509.1,
BAC04721.1,
EAW86333.1,
AAG60689.1,
AAI15738.1,
EAW86332.1,
BAA92646.1,
BAA91369.1
Ensembl_TRS:
ENST00000356352,
ENST00000397053,
ENST00000357604
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000348708,
ENSP00000350221,
ENSP00000380244
RefSeq:
NP_056357.1,
NP_542166.1,
XP_011517751.1
|
| Others |
UniRef100:
UniRef100_Q9HAU5
UniRef90:
UniRef90_Q9HAU5
UniRef50:
UniRef50_Q9HAU5
UniGene:
Hs.370689,
Hs.610110,
Hs.732383
CCDS:
CCDS7086.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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