| Type | Description |
|---|---|
| Definition | pleckstrin 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 10:23:00 | High PLEK2 expression is associated with migration and invasion in non-small cell lung cancer. | 31498891 |
| 2019-12-07 11:06:00 | On the basis of these collective data, we propose that PLEK2 promotes the invasion and metastasis of GBC by EGFR/CCL2 pathway and PLEK2 can serve as a potential therapeutic target for GBC treatment. | 31182136 |
| 2011-11-12 10:25:00 | expression of PLEK2, the strongest gene to classify melanoma patients, in CD45(-) subsets illustrates the importance of analyzing whole blood cells for biomarker studies | 21698244 |
| 2010-01-21 00:00:00 | pleckstrin-2 uses its modular domains to bind to membrane-associated phosphatidylinositols generated by PI3K, whereby it coordinates with the actin cytoskeleton in lymphocyte spreading and immune synapse formation. | 17008542 |
| 2010-01-21 00:00:00 | Pleckstrin 2 was cloned; its mRNA is widely expressed in a variety of cell lines. | 15865208 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
PLEK2_HUMAN
UniprotKB:
Q9NYT0
UniParc:
UPI0000035D89
EMBL:
BC001226,
BC008056,
AF228603
Ensembl:
ENSG00000100558
KO:
hsa:26499
|
| Nucleutide sequences |
EMBL-CDS:
AAF34791.1,
AAH08056.2,
AAH01226.1
Ensembl_TRS:
ENST00000216446
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000216446
RefSeq:
NP_057529.1
|
| Others |
UniRef100:
UniRef100_Q9NYT0
UniRef90:
UniRef90_Q9NYT0
UniRef50:
UniRef50_Q9NYT0
UniGene:
Hs.170473
CCDS:
CCDS9782.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31498891 |
Int J Cancer Dong-Ming Wu , Shi-Hua Deng , Jin Zhou , Rong Han , Teng Liu , Ting Zhang , Jing Li , Jian-Ping Chen , Ying Xu |
2020-05-01 | - |
| 31182136 |
PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway. J. Exp. Clin. Cancer Res. Hui Shen , Min He , Ruirong Lin , Ming Zhan , Sunwang Xu , Xince Huang , Chu Xu , Wei Chen , Yanhua Yao , Man Mohan , Jian Wang |
2019-06-10 | - |
| 30639242 |
The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. Mol. Cell Joanna R Kovalski , Aparna Bhaduri , Ashley M Zehnder , Poornima H Neela , Yonglu Che , Glenn G Wozniak , Paul A Khavari |
2019-02-21 | - |
| 30463901 |
BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression. Genes Dev. Lei Yu , Natee Jearawiriyapaisarn , Mary P Lee , Tomonori Hosoya , Qingqing Wu , Greggory Myers , Kim-Chew Lim , Ryo Kurita , Yukio Nakamura , Anne B Vojtek , Jean-François Rual , James Douglas Engel |
2018-12-01 | - |
| 30232004 |
Cell Rep Christopher G Abraham , Michael P Ludwig , Zdenek Andrysik , Ahwan Pandey , Molishree Joshi , Matthew D Galbraith , Kelly D Sullivan , Joaquin M Espinosa |
2018-09-18 | - |
| 29467282 |
Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. Jan B Heidelberger , Andrea Voigt , Marina E Borisova , Giuseppe Petrosino , Stefanie Ruf , Sebastian A Wagner , Petra Beli |
2018-04-01 | - |
| 24104479 |
Mol. Syst. Biol. Franco J Vizeacoumar , Roland Arnold , Frederick S Vizeacoumar , Megha Chandrashekhar , Alla Buzina , Jordan T F Young , Julian H M Kwan , Azin Sayad , Patricia Mero , Steffen Lawo , Hiromasa Tanaka , Kevin R Brown , Anastasia Baryshnikova , Anthony B Mak , Yaroslav Fedyshyn , Yadong Wang , Glauber C Brito , Dahlia Kasimer , Taras Makhnevych , Troy Ketela , Alessandro Datti , Mohan Babu , Andrew Emili , Laurence Pelletier , Jeff Wrana , Zev Wainberg , Philip M Kim , Robert Rottapel , Catherine A O'Brien , Brenda Andrews , Charles Boone , Jason Moffat |
2013-01-01 |
ADAM10,
RAMP1,
BCAS2,
ANAPC10,
CEBPD,
CCT7,
YME1L1,
KDM5B,
TBC1D8,
TREX2,
CREBBP,
ZNF358,
SREK1,
C12orf66,
CSNK2B,
CDC42EP5,
KIAA2026,
COCH,
DHFR,
CYB5R3,
RILPL2,
EME2,
ELK4,
STK32A,
ENO2,
SLC36A1,
FANCD2,
VWCE,
ALDH3B1,
ATXN7L1,
ICK,
SNW1,
SNRNP200,
AKR1B1,
RFTN1,
SLC9A8,
PIGN,
KPNA6,
OSBP2,
MMS22L,
PRPF31,
FBXL6,
BLOC1S1,
PLEK2,
POLM,
GPER1,
C16orf72,
GTPBP8,
SLC25A6,
ZBTB48,
XIAP,
ST8SIA6,
ZNF181,
IDH2,
KRAS,
HES5,
LLGL2,
LTA4H,
LTK,
MXD1,
MBP,
MDFI,
DNAJB9,
MTNR1A,
NAB1,
NONO,
NOTCH1,
NUMA1,
NUP98,
OPRL1,
PBX3,
TXNDC11,
NDUFA13,
TFB1M,
RNFT1,
POLR3K,
LUC7L3,
FXYD1,
POLD2,
POLR2L,
POU3F3,
INO80,
SAMD4B,
HES6,
TTC27,
CDC37L1,
CDK5RAP2,
KMT2E,
NXT2,
MAP2K1,
B2M,
PSMA3,
PSMB2,
DUS3L,
ARNTL2,
NT5M,
PSMD1,
PTEN,
CWC22
|
| 22939629 |
A census of human soluble protein complexes. Cell Pierre C Havugimana , G Traver Hart , Tamás Nepusz , Haixuan Yang , Andrei L Turinsky , Zhihua Li , Peggy I Wang , Daniel R Boutz , Vincent Fong , Sadhna Phanse , Mohan Babu , Stephanie A Craig , Pingzhao Hu , Cuihong Wan , James Vlasblom , Vaqaar-un-Nisa Dar , Alexandr Bezginov , Gregory W Clark , Gabriel C Wu , Shoshana J Wodak , Elisabeth R M Tillier , Alberto Paccanaro , Edward M Marcotte , Andrew Emili |
2012-08-31 |
SRB2,
TRA1,
MED6,
CDH2,
DDTL,
ABI1,
SRA1,
UQCRFS1P1,
SNRPGP15,
ZNF316,
LOC100132057,
PDCD6IP,
PDCD6,
MED16,
PIGK,
WASH1,
CHAF1A,
TOM1L1,
HMGXB4,
RANBP9,
SMC4,
UBA2,
SAE1,
FARSB,
ABCB6,
ABCF2,
TIMM23B,
SCAMP3,
DPP3,
HUWE1,
TSSC4,
PDCD7,
USH1C,
PQBP1,
ARPC5,
ARPC4,
ARPC3,
ARPC1B,
ACTR3,
ACTR2,
NUBP2,
TSFM,
PPIF,
ARPC2,
RAD50,
PREB,
ACTR1B,
ACTR1A,
RASGRP1,
LRPPRC,
PDIA6,
TRAP1,
RBM12,
G3BP1,
SUGP2,
TRIM28,
WASF2,
SLC25A13,
SORBS3,
ALYREF,
TXNDC9,
CDK4,
PRMT3,
PSME3,
MPHOSPH6,
CDK5,
NUTF2,
EIF1,
FLOT1,
PSMD14,
CDK7,
ADAM10,
PLIN3,
STX6,
MSLN,
HNRNPR,
MRPS31,
TIMM17B,
RIDA,
POP7,
SRRM1,
CDK9,
STAM2,
SF3B4,
ZMPSTE24,
STUB1,
UBE4B,
BET1,
CWC27,
SAP18,
SMNDC1,
BCAS2,
EIF1B,
SF3A1,
MAEA,
KATNB1,
TCIRG1,
RTN3,
LANCL1
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21698244 |
Transcriptome profiling of whole blood cells identifies PLEK2 and C1QB in human melanoma. PLoS One Yuchun Luo , Steven Robinson , Junichi Fujita , Lisa Siconolfi , Jay Magidson , Carl K Edwards , Karl Wassmann , Kathleen Storm , David A Norris , Danute Bankaitis-Davis , William A Robinson , Mayumi Fujita |
2011-01-01 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
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| 排名 | 研究人员 | 文献 |
|---|---|---|
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