| Type | Description |
|---|---|
| Definition | pyruvate carboxylase |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:29:00 | Overexpression of Pyruvate Carboxylase Is Correlated With Colorectal Cancer Progression and Supports Growth of Invasive Colon Cancer HT-29 | 33109566 |
| 2020-04-04 11:20:00 | Study compares type A and type C patients with pyruvate carboxylase deficiency (PCD). Type C PCD is not associated to homozygous variants in PC. In silico modeling found that variants lead to type A or type C phenotype based on the destabilization between the two major enzyme conformers. | 30870574 |
| 2019-05-11 11:56:00 | Our studies indicate that PC is specifically required for the growth of breast cancer that has disseminated to the lungs. Overall, these findings point to the potential of targeting PC for the treatment of pulmonary metastatic breast cancer | 30005601 |
| 2018-12-22 10:06:00 | PC enzyme activity is much higher in the highly invasive breast cancer cell line MDA-MB-231 than in less invasive breast cancer cell lines. Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate. | 27890529 |
| 2017-11-26 00:01:00 | breast cancer cells proliferating as lung metastases activate PC-dependent anaplerosis in response to the lung microenvironment. | 27732858 |
| Type | IDs |
|---|---|
| Synonymous | PCB |
| Gene |
UniProtKB-ID:
PYC_HUMAN,
A0A024R5C5_HUMAN
UniprotKB:
P11498,
A0A024R5C5
UniParc:
UPI0000132BC4,
UPI00017A7951
EMBL:
AP003176,
M26122,
AK297705,
S72370,
AP000485,
U30891,
CH471076,
U04641,
BC011617,
K02282
Ensembl:
ENSG00000173599
KO:
hsa:5091
|
| Nucleutide sequences |
EMBL-CDS:
AAA36423.1,
AAA60033.1,
AAA82937.1,
AAB31500.1,
BAG60062.1,
AAH11617.1,
AAA99537.1,
EAW74569.1,
EAW74568.1,
EAW74572.1,
EAW74570.1,
EAW74571.1
Gene_ORFName:
hCG_20121
Ensembl_TRS:
ENST00000393960,
ENST00000393958,
ENST00000393955,
ENST00000651854,
ENST00000529047,
ENST00000652125,
ENST00000651036,
ENST00000524491
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000377532,
ENSP00000435905,
ENSP00000498994,
ENSP00000434192,
ENSP00000377530,
ENSP00000377527,
ENSP00000498406,
ENSP00000498302
RefSeq:
XP_006718642.1,
XP_011543389.1,
XP_016873359.1,
XP_006718641.1,
XP_016873360.1,
NP_071504.2,
XP_011543388.1,
NP_000911.2,
NP_001035806.1,
XP_005274089.1,
XP_016873358.1,
XP_005274088.1,
XP_016873361.1,
XP_016873357.1
|
| Others |
UniRef100:
UniRef100_P11498
UniRef90:
UniRef90_P11498
UniRef50:
UniRef50_P11498
UniGene:
Hs.89890
CCDS:
CCDS8152.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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