| Type | Description |
|---|---|
| Definition | osteoclast stimulating factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-09-07 10:49:00 | We utilized a structure-based approach to pinpoint the binding interface to a strictly conserved cluster of residues on the surface of RP2 that spans both the C- and N-terminal domains of the protein, and which is structurally distinct from the ARL3-binding site.RP2 is a positive regulator of cell motility in vitro, recruiting OSTF1 to the cell membrane and preventing its interaction with the migration regulator Myo1E. | 29361551 |
| 2011-10-15 10:26:00 | Data show that SH3P2 was phosphorylated on Ser(202) by ribosomal S6 kinase (RSK) in an ERK pathway-dependent manner, and such phosphorylation inhibited the ability of SH3P2 to suppress cell motility. | 21501342 |
| 2010-06-30 22:05:00 | Observational study of gene-disease association. (HuGE Navigator) | 20424473 |
| 2010-01-21 00:00:00 | SH3P2, a novel component of adhesion sites, is involved in Cbl and Src-mediated pathways | 15135048 |
| 2010-01-21 00:00:00 | The peptide-binding groove of OSTF-SH3 domain adopts a conformation different from other SH3 domains and probably needs a conformational switch for binding to its proline-rich ligand; this status is possibly regulated by the C-terminal ankyrin repeats. | 19137598 |
| Type | IDs |
|---|---|
| Synonymous | OSF, SH3P2, bA235O14.1 |
| Gene |
UniProtKB-ID:
OSTF1_HUMAN
UniprotKB:
Q92882
UniParc:
UPI0000210B5F
EMBL:
BC007459,
AK222596,
U63717,
AL133548
Ensembl:
ENSG00000134996
KO:
hsa:26578
|
| Nucleutide sequences |
EMBL-CDS:
BAD96316.1,
AAH07459.1,
AAB06396.1
Ensembl_TRS:
ENST00000346234
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000340836
RefSeq:
XP_016870111.1,
XP_006717116.1,
XP_011516826.1,
XP_006717118.1,
NP_036515.4,
XP_011516827.1
|
| Others |
UniRef100:
UniRef100_Q92882
UniRef90:
UniRef90_Q92882
UniRef50:
UniRef50_Q92882
UniGene:
Hs.494192
CCDS:
CCDS6651.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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