| Type | Description |
|---|---|
| Definition | density regulated re-initiation and release factor |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:59:00 | DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4. | 32938922 |
| 2019-04-27 10:18:00 | Present the crystal structure of MCTS1 bound to a fragment of DENR. Based on this structure, we identify and experimentally validate that DENR residues Glu42, Tyr43, and Tyr46 are important for MCTS1 binding and that MCTS1 residue Phe104 is important for tRNA binding. Mutation of these residues reveals that DENR-MCTS1 dimerization and tRNA binding are both necessary for DENR and MCTS1 to promote translation reinitiation. | 29889857 |
| 2019-03-16 10:16:00 | findings elucidate further the mechanism of regulation of DENR-MCT-1 activities in unconventional translation initiation, reinitiation, and recycling. | 30584092 |
| 2018-04-07 11:15:00 | findings elucidate how the DENR-MCT-1 dimer interacts with the ribosome and have functional implications for the mechanism of unconventional translation initiation and reinitiation. | 28723557 |
| 2018-01-02 09:51:00 | DENR binds to the P-site of the 40S ribosomal subunit and together with MCTS1 forms a tRNA binding surface and interfere with eIF1/eIF2/eIF3 binding, thus operating in ribosome recycling and translation re-initiation | 28723557 |
| Type | IDs |
|---|---|
| Synonymous | DRP, DRP1, SMAP-3 |
| Gene |
UniProtKB-ID:
DENR_HUMAN,
A0A024RBR3_HUMAN
UniprotKB:
O43583,
A0A024RBR3
UniParc:
UPI000012918D
EMBL:
AF038554,
BC007860,
AC026331,
AF103800,
CH471054,
AB014731,
AC027290
Ensembl:
ENSG00000139726
KO:
hsa:8562
|
| Nucleutide sequences |
EMBL-CDS:
AAC02985.2,
BAB20268.1,
AAH07860.1,
AAF02420.1,
EAW98338.1,
EAW98342.1
Gene_ORFName:
H14,
hCG_33191
Ensembl_TRS:
ENST00000280557
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000280557
RefSeq:
NP_003668.2
|
| Others |
UniRef100:
UniRef100_O43583
UniRef90:
UniRef90_O43583
UniRef50:
UniRef50_O43583
UniGene:
Hs.22393
CCDS:
CCDS45003.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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