| Type | Description |
|---|---|
| Definition | RNA 2',3'-cyclic phosphate and 5'-OH ligase |
| Date | Results | Publications |
|---|---|---|
| 2017-11-04 11:35:00 | This paper presents a homology model of human RtcB (hRtcB). The structure was analyzed in terms of stereochemical quality, folding reliability, secondary structure, druggability of the active site binding pocket and its metal-binding microenvironment. | 28707320 |
| 2015-07-25 10:58:00 | RTCB, the catalytic subunit of the tRNA ligase complex, and its co-factor archease mediate XBP1 mRNA splicing both in vitro and in vivo. | 25378478 |
| 2015-02-14 11:05:00 | hCLE/C14orf166 associates with DDX1, HSPC117, and FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. | 24608264 |
| 2015-01-31 11:51:00 | Over-expression of HSPC117 mRNA reduced MMP 2 and MMP 14 mRNA expression, while TIMP 2 mRNA expression was up-regulated. | 24941254 |
| 2011-03-05 10:42:00 | study identified HSPC117, a member of the UPF0027 (RtcB) family, as the essential subunit of a tRNA ligase complex; RNA interference-mediated depletion of HSPC117 inhibited maturation of intron-containing pre-tRNA both in vitro and in living cells | 21311021 |
| Type | IDs |
|---|---|
| Synonymous | C22orf28, DJ149A16.6, FAAP, HSPC117 |
| Gene |
UniProtKB-ID:
RTCB_HUMAN
UniprotKB:
Q9Y3I0
UniParc:
UPI000006E0DE
EMBL:
BC010308,
BC002970,
CH471095,
AL050255,
BC016707,
AL137272,
AL021937,
AK312503,
AF155658,
CR457175,
AF161466,
CR456450,
BC000151
Ensembl:
ENSG00000100220
KO:
hsa:51493
|
| Nucleutide sequences |
EMBL-CDS:
CAB43357.1,
AAF67477.1,
CAG30336.1,
AAH02970.1,
AAH16707.1,
EAW60021.1,
BAG35405.1,
AAF29081.1,
CAG33456.1,
AAH10308.1,
CAB70670.1,
AAH00151.1
Gene_ORFName:
HSPC117
Ensembl_TRS:
ENST00000216038
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000216038
RefSeq:
NP_055121.1
|
| Others |
UniRef100:
UniRef100_Q9Y3I0
UniRef90:
UniRef90_Q9Y3I0
UniRef50:
UniRef50_Q9Y3I0
UniGene:
Hs.474643
CCDS:
CCDS13905.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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