| Type | Description |
|---|---|
| Definition | ubiquitin like modifier activating enzyme 3 |
| Date | Results | Publications |
|---|---|---|
| 2016-02-06 11:05:00 | The study demonstrated that two mutations in UBA3 which were not previously reported confer MLN4924 resistance to MLN4924, a selective NEDD8-activating enzyme inhibitor. | 24691136 |
| 2015-08-08 10:35:00 | E1 (NAE1 and UBA3) and E2 (UBC12) enzymes, as well as global NEDD8 conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma | 25229838 |
| 2014-10-25 10:13:00 | Report role for neddylation via Nedd8-activating enzyme in the regulation of tumor angiogenesis. | 24525735 |
| 2013-03-30 12:18:00 | Demonstrated that Uba3-betaGD is an independently folded domain in solution and that residues involved in E2 binding are absent from the NMR spectrum, indicating that the E2-binding surface on Uba3-betaGD interconverts between multiple conformations. | 22821745 |
| 2010-01-21 00:00:00 | structure and mutational analysis of human APPBP1-UBA3, the heterodimeric E1 enzyme for NEDD8 | 12646924 |
| Type | IDs |
|---|---|
| Synonymous | NAE2, UBE1C, hUBA3 |
| Gene |
UniProtKB-ID:
UBA3_HUMAN
UniprotKB:
Q8TBC4
UniParc:
UPI000015F415,
UPI00001E058C
EMBL:
AL117566,
AF046024,
AK002159,
AC092060,
AC109587,
BC022853,
AK289392,
CH471055,
AB012190
Ensembl:
ENSG00000144744
KO:
hsa:9039
|
| Nucleutide sequences |
EMBL-CDS:
EAW65470.1,
AAC27648.1,
BAF82081.1,
BAG51021.1,
BAA33144.1,
AAH22853.1,
CAB55996.2
Ensembl_TRS:
ENST00000349511,
ENST00000361055
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000340041,
ENSP00000354340
RefSeq:
NP_001350790.1,
XP_011532512.1,
NP_937838.1,
NP_003959.3
|
| Others |
UniRef100:
UniRef100_Q8TBC4
UniRef90:
UniRef90_Q8TBC4
UniRef50:
UniRef50_Q8TBC4
UniGene:
Hs.154320
CCDS:
CCDS2909.1,
CCDS2910.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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