| Type | Description |
|---|---|
| Definition | cell cycle and apoptosis regulator 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:16:00 | A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo. | 31591441 |
| 2020-08-15 14:43:00 | Human cell cycle and apoptosis regulator 2 (DBC1) regulates transcriptional elongation factor ELL stability involving HDAC3, p300, and Siah1. DBC1 competes with histone deacetylase 3 (HDAC3) for the same binding sites on ELL and thus increases its acetylation and stability. Knockdown of DBC1 reduces ELL levels and expression of a significant number of genes, including those involved in glucose metabolism. | 32152128 |
| 2020-05-02 12:03:00 | Because DBC1 maintains p53 stability in the nucleus, where p53 exerts its tumor-suppressive transcriptional function, replacement of DBC1 functionality in DBC1-deleted tumors might enhance p53 function and chemosensitivity for therapeutic benefit. | 30893604 |
| 2019-11-16 12:44:00 | DBC1 is required for LEF1/beta-catenin complex formation on the MACC1 enhancer and for long-distance enhancer-promoter interaction of the MACC1 locus. DBC1 overexpression further increased MACC1 expression in colonospheres and promoted sphere-forming abilities of colon cancer cells and drug resistance of colonospheres. | 30082743 |
| 2019-10-12 12:26:00 | data demonstrate that Ajuba functions as a novel co-activator of ERalpha and that Ajuba/DBC1/CBP/p300 ternary complex may be a new target for developing therapeutics to treat breast cancer | 30597111 |
| Type | IDs |
|---|---|
| Synonymous | DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC |
| Gene |
UniProtKB-ID:
CCAR2_HUMAN
UniprotKB:
Q8N163
UniParc:
UPI0000070A46,
UPI0000680ADB
EMBL:
AC037459,
AK314535,
BX640952,
CH471080,
BC065495,
AK096547,
AL834351,
BC018269,
AF293335,
AL834352,
AL137523,
AL834162,
AB075847
Ensembl:
ENSG00000158941
KO:
hsa:57805
|
| Nucleutide sequences |
EMBL-CDS:
AAG02472.1,
EAW63658.1,
EAW63661.1,
CAD39016.1,
CAE45976.1,
AAH18269.2,
CAB70788.3,
BAB85553.1,
BAG37126.1,
CAD38866.1,
AAH65495.1,
CAD39017.1
Ensembl_TRS:
ENST00000389279,
ENST00000308511
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000373930,
ENSP00000310670
RefSeq:
XP_011542906.1,
NP_001349997.1,
NP_001349998.1,
NP_066997.3
|
| Others |
UniRef100:
UniRef100_Q8N163
UniRef90:
UniRef90_Q8N163
UniRef50:
UniRef50_Q8N163
UniGene:
Hs.744848
CCDS:
CCDS34863.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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