| Type | Description |
|---|---|
| Definition | activator of HSP90 ATPase activity 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 14:06:00 | Data support the multi-step nature of the Hsp90/Aha1-interaction, where the N-terminal domain of Aha1 interacts with both Hsp90 M domains upon induction of a partially closed conformation of the Hsp90 dimer. In addition, the data indicate that the C-terminal domain of Aha1 can adopt several conformations leading to a dynamic, polymorphic complex. | 31299134 |
| 2018-06-09 10:56:00 | Aha1 colocalized with tau pathology in brain tissue, and this association positively correlated with Alzheimer disease progression. | 28827321 |
| 2015-04-25 12:17:00 | These results suggest that differences in the middle domain of Hsp90alpha and Hsp90beta may be responsible for the isoform-specific interactions with selected proteins. | 25486457 |
| 2015-04-18 11:23:00 | Aha1 may promote disposal of folding defective proteins by the cellular protein quality control. | 25378400 |
| 2013-01-12 11:15:00 | Modulation of Hsp90 activity by AHA1 regulates VEGF signaling to eNOS and angiogenesis. | 22859491 |
| Type | IDs |
|---|---|
| Synonymous | AHA1, C14orf3, hAha1, p38 |
| Gene |
UniProtKB-ID:
AHSA1_HUMAN,
G3V438_HUMAN
UniprotKB:
O95433,
G3V438
UniParc:
UPI00021CF2AC,
UPI00017A7F99,
UPI0000127BE0
EMBL:
AF164791,
AK313824,
AJ243310,
BC000321,
AF111168,
AK300766,
AF161440,
CH471061,
BC007398
Ensembl:
ENSG00000100591
KO:
hsa:10598
|
| Nucleutide sequences |
EMBL-CDS:
BAG36559.1,
AAH00321.1,
EAW81291.1,
CAB45684.1,
BAG62431.1,
AAF80755.1,
AAD09623.1,
AAF29000.1,
AAH07398.2
Gene_ORFName:
HSPC322
Ensembl_TRS:
ENST00000535854,
ENST00000216479,
ENST00000555133
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000440108,
ENSP00000216479,
ENSP00000451569
RefSeq:
NP_001308370.1,
NP_036243.1
|
| Others |
UniRef100:
UniRef100_O95433
UniRef90:
UniRef90_O95433
UniRef50:
UniRef50_O95433
UniGene:
Hs.204041
CCDS:
CCDS9863.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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