| Type | Description |
|---|---|
| Definition | pre-mRNA processing factor 40 homolog B |
| Date | Results | Publications |
|---|---|---|
| 2019-11-09 12:10:00 | Study characterizes the transcriptomic regulation of PRPF40B in K562 cells upon knockout (KO) and rescue with MDS mutations, to reveal a set of targets with weak splice sites and A-rich motifs. Importantly, PRPF40B KO up-regulated a hypoxia signature which, together with its low expression in AML, suggests a role of PRPF40B in myeloid leukemias. | 31088860 |
| 2015-04-18 11:18:00 | Placing our data in a functional context, we also show that PRPF40B depletion increased Fas/CD95 receptor number and cell apoptosis, which suggests the ability of PRPF40B to alter the alternative splicing of key apoptotic genes to regulate cell survival | 25605964 |
| Type | IDs |
|---|---|
| Synonymous | HYPC |
| Gene |
UniProtKB-ID:
PR40B_HUMAN,
F8VU11_HUMAN
UniprotKB:
Q6NWY9,
F8VU11
UniParc:
UPI000034E5B3,
UPI0000E5961C,
UPI00015E0FC4,
UPI000006CEE9,
UPI00001C08D9
EMBL:
AL137459,
AK123353,
BC067364,
AC020612,
AF049525,
CH471111,
BC050398,
AK027117,
AL834216
Ensembl:
ENSG00000110844
KO:
hsa:25766
|
| Nucleutide sequences |
EMBL-CDS:
AAH50398.1,
EAW58085.1,
CAB70747.1,
AAC27503.1,
CAD38898.1,
BAB15662.1,
AAH67364.1,
EAW58084.1
Gene_ORFName:
hCG_20201
Ensembl_TRS:
ENST00000261897,
ENST00000380281,
ENST00000548825
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000369634,
ENSP00000261897,
ENSP00000448073
RefSeq:
NP_001365965.1,
NP_001365960.1,
NP_001365962.1,
XP_011536438.1,
NP_001365963.1,
NP_001365961.1,
XP_011536440.1,
NP_001365966.1,
XP_011536442.1,
XP_011536445.1,
XP_006719388.1,
NP_001365959.1,
XP_011536441.1,
XP_016874627.1,
XP_011536439.1,
NP_001350536.2,
XP_016874628.1,
XP_016874624.1,
NP_036404.1,
NP_001365964.1,
XP_011536437.1,
XP_006719387.1,
NP_001026868.2
|
| Others |
UniRef100:
UniRef100_Q6NWY9,
UniRef100_F8VU11
UniRef90:
UniRef90_Q6NWY9
UniRef50:
UniRef50_Q6NWY9
UniGene:
Hs.706827
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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