| Type | Description |
|---|---|
| Definition | CCR4-NOT transcription complex subunit 3 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:43:00 | The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy. | 31474762 |
| 2020-07-25 11:14:00 | De novo variants in CNOT3 cause a variable neurodevelopmental disorder. | 31201375 |
| 2020-05-09 13:40:00 | CCR4-NOT transcription complex subunit 3 (CNOT3) is up-regulated in lung cancer tissues and is associated with poor prognosis of the patients. Knocking down CNOT3 expression sensitizes cisplatin-resistant A549 (A549/DDP) cells to cisplatin-induced apoptosis. CNOT3 depletion up-regulates the expression level of RIPK3 and the enhanced apoptosis is mediated by the elevated RIPK3 to further trigger Caspase 8 activation. | 31177396 |
| 2019-05-18 12:06:00 | Increased expression of MHC II genes after knock-down or knock-out of either CNOT1, CNOT2, or CNOT3 subunit was seen in a variety of cell systems and also in naive macrophages from CNOT3 conditional knock-out mice. | 28615693 |
| 2019-05-04 10:05:00 | The up-regulation of CNOT3 facilitates the development of non-small cell lung cancer. | 30531840 |
| Type | IDs |
|---|---|
| Synonymous | LENG2, NOT3, NOT3H |
| Gene |
UniProtKB-ID:
CNOT3_HUMAN,
A0A024R4R3_HUMAN
UniprotKB:
O75175,
A0A024R4R3
UniParc:
UPI00000729AD
EMBL:
CH471135,
AF180474,
BC016474,
AL133647,
AB014591
Ensembl:
ENSG00000274941,
ENSG00000275979,
ENSG00000088038,
ENSG00000273943,
ENSG00000277114,
ENSG00000277600,
ENSG00000274176,
ENSG00000276082,
ENSG00000274616,
ENSG00000277615
KO:
hsa:4849
|
| Nucleutide sequences |
EMBL-CDS:
AAF29828.1,
AAH16474.1,
CAB63766.1,
BAA31666.2,
EAW72194.1,
EAW72192.1
Gene_ORFName:
hCG_1812176
Ensembl_TRS:
ENST00000613528,
ENST00000617982,
ENST00000616359,
ENST00000221232,
ENST00000620419,
ENST00000610883,
ENST00000613752,
ENST00000620970,
ENST00000619854,
ENST00000611252,
ENST00000614649,
ENST00000622131,
ENST00000620573,
ENST00000612924,
ENST00000619567,
ENST00000618405,
ENST00000620060,
ENST00000616910,
ENST00000358389,
ENST00000615030
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000480258,
ENSP00000483431,
ENSP00000479987,
ENSP00000483968,
ENSP00000480697,
ENSP00000480585,
ENSP00000483036,
ENSP00000484794,
ENSP00000483692,
ENSP00000481681,
ENSP00000478280,
ENSP00000480988,
ENSP00000483604,
ENSP00000480876,
ENSP00000481924,
ENSP00000484040,
ENSP00000478956,
ENSP00000483882,
ENSP00000351159,
ENSP00000221232
RefSeq:
XP_005278338.1,
XP_011525295.1,
XP_011525294.1,
XP_005278337.1,
XP_005278336.1,
XP_005278339.1,
NP_055331.1
|
| Others |
UniRef100:
UniRef100_O75175
UniRef90:
UniRef90_O75175
UniRef50:
UniRef50_O75175
UniGene:
Hs.343571
CCDS:
CCDS12880.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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