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5829 PXN

5829

PXN

paxillin

protein-coding

Homo sapiens

基因描述

Type Description
Definition paxillin

研究结论

Date Results Publications
2020-04-18 12:18:00 Microarray, gain, or loss of function and luciferase report assays revealed the direct regulatory effect of ETV4 on the expression of focal adhesion gene PXN and matrix metalloproteinase 1 (MMP1), and PXN and/or MMP1 inhibition partially abolished cell proliferation and migration induced by ETV4. 31670855
2019-02-02 10:44:00 Glucosamine affects signaling pathway activation of NK-92 immune cells, changing the phosphorylation of FOXO1, paxillin, and the ERK map kinase pathway 30016365
2018-11-03 12:05:00 Data suggest that FGFR3 with mutation found in patients with SADDAN (but not FGFR3 with mutation found in patients with TDII) affects cytoskeleton organization in chondrocytes by inducing tyrosine hyperphosphorylation of paxillin. (FGFR3 = fibroblast growth factor receptor 3; SADDAN = Severe Achondroplasia with Developmental Delay and Acanthosis Nigricans; TDII = Thanatophoric Dysplasia type II) 29242050
2018-09-15 12:04:00 overexpression of Paxillin significantly decreased tumor volume of colorectal cancer; miR-24 was overexpressed in natural killer cells and inhibited paxillin expression. 29494963
2018-09-01 10:52:00 XIST positively regulated PXN levels by sponging miR-137 in vitro and in vivo. Collectively, our study provided the evidence for the cross-talk between XIST, miR-137, and PXN, shedding light on the therapy for non-small cell lung cancer . 29337100

名称对应

Type IDs
Gene
UniProtKB-ID: PAXI_HUMAN, A0A140VJQ8_HUMAN
UniprotKB: P49023, A0A140VJQ8
UniParc: UPI00001FBC71, UPI0001711D29, UPI000013C8CD, UPI0000E00CD4
EMBL: D86863, U14588, CH471054, U87944, BC136794, AC004263, AK314204, D86862, U87943, HM005447, BC144410, BX648777, U87942, U87945, U87941, BC136787, U87946
Ensembl: ENSG00000089159
KO: hsa:5829
Nucleutide sequences
EMBL-CDS: AAC50104.1, AAD00648.1, AAI44411.1, CAI46024.1, AAC05175.1, BAG36880.1, AAI36795.1, AAI36788.1, BAA18998.1, BAA18997.1, AEE61045.1, EAW98179.1
Gene_ORFName: hCG_27772
Ensembl_TRS: ENST00000424649, ENST00000267257, ENST00000458477, ENST00000228307
Protein sequencees
Ensembl_PRO: ENSP00000228307, ENSP00000395536, ENSP00000267257, ENSP00000391283
RefSeq: XP_016875229.1, XP_006719599.1, XP_024304877.1, NP_001372913.1, XP_006719597.1, NP_001372914.1, XP_016875215.1, XP_016875223.1, XP_011536924.1, XP_016875222.1, XP_016875219.1, XP_005253974.1, NP_001372911.1, XP_024304875.1, XP_016875232.1, XP_016875227.1, NP_001372919.1, XP_016875231.1, XP_016875228.1, NP_001372910.1, NP_001372916.1, NP_001372915.1, XP_016875225.1, NP_001230685.1, XP_016875224.1, NP_001074324.1, XP_016875221.1, XP_024304878.1, NP_002850.2, XP_016875226.1, NP_001372918.1, NP_001372912.1, NP_079433.3, XP_006719598.1, XP_011536925.1, XP_006719595.1, XP_016875218.1, NP_001372917.1, XP_024304876.1
Others
UniRef100: UniRef100_P49023
UniRef90: UniRef90_P49023
UniRef50: UniRef50_P49023
UniGene: Hs.446336
CCDS: CCDS44998.1, CCDS44996.1, CCDS44997.1, CCDS58281.1

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