| Type | Description |
|---|---|
| Definition | minichromosome maintenance complex component 3 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:11:00 | Elevated expression of minichromosome maintenance 3 indicates poor outcomes and promotes G1/S cell cycle progression, proliferation, migration and invasion in colorectal cancer. | 32597491 |
| 2021-02-27 13:46:00 | Gene expression profiling revealed MCM3 to be a better marker than Ki67 in prognosis of invasive ductal breast carcinoma patients. | 31980982 |
| 2019-12-07 12:28:00 | Results show that found DNA replication initiation protein MCM3 was upregulated in hepatocellular carcinoma (HCC) tissues and cells and its expression correlated with poor outcome and radioresistance. MCM3 promoted radioresistance through activating NF-kappaB pathway, strengthening the role of MCM subunits in the tumor progression. These Findings revealed an independent prognostic factor of MCM3 for HCC. | 31208444 |
| 2019-11-02 11:32:00 | Study characterize the interaction of Keap1, a central antioxidant response regulator in Metazoa, with the replicative helicase subunit protein MCM3. Analysis suggests that structural determinants of the interaction of Keap1 with its critical downstream target - Nrf2 master transactivator of oxidative stress response genes - may have evolved in evolution to mimic the conserved helix-2-insert motif of MCM3. | 30108253 |
| 2019-09-28 12:46:00 | Data report that MCM3 is a novel target of Pin1 through directly interacting with Pin1 WW domain. Proline-directed phosphorylation of MCM3 at S112 and T722 are crucial for the interaction with Pin1. MCM3 as a subunit of the MCM2-7 heterocomplex is part of the pre-replication complex responsible for replication licensing and is implicated in the formation of the replicative helicase during the replication progression. | 30316783 |
| Type | IDs |
|---|---|
| Synonymous | HCC5, P1-MCM3, P1.h, RLFB |
| Gene |
UniProtKB-ID:
MCM3_HUMAN,
A0A499FHX9_HUMAN,
B4DUQ9_HUMAN,
A0A0S2Z4T1_HUMAN
UniprotKB:
P25205,
A0A499FHX9,
B4DUQ9,
A0A0S2Z4T1
UniParc:
UPI000012ED97,
UPI00026C2428,
UPI0000EE4F08,
UPI00017A7F91
EMBL:
AK300754,
AY621074,
D38073,
BC003509,
AL034343,
BC001626,
AK301704,
X62153,
CH471081,
KU178170
Ensembl:
ENSG00000112118
KO:
hsa:4172
|
| Nucleutide sequences |
EMBL-CDS:
BAG63176.1,
AAH01626.1,
AAT27321.1,
CAA44078.2,
BAA07267.1,
EAX04367.1,
AAH03509.2,
BAG62421.1,
ALQ33628.1
Ensembl_TRS:
ENST00000616552,
ENST00000596288,
ENST00000229854
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000472940,
ENSP00000480987,
ENSP00000229854
RefSeq:
NP_001353303.1,
NP_001353298.1,
NP_001353299.1,
NP_001353300.1,
NP_001257401.2,
NP_001353302.1,
NP_001353304.1,
NP_002379.4,
NP_001353301.1
|
| Others |
UniRef100:
UniRef100_B4DUQ9,
UniRef100_A0A499FHX9,
UniRef100_P25205
UniRef90:
UniRef90_P25205,
UniRef90_E2RF73
UniRef50:
UniRef50_P25205
UniGene:
Hs.179565
CCDS:
CCDS4940.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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