| Type | Description |
|---|---|
| Definition | poly(A) binding protein nuclear 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:13:00 | Regulation of Kv11.1 Isoform Expression by Polyadenylate Binding Protein Nuclear 1. | 33467093 |
| 2021-04-03 13:30:00 | PABPN1, a Target of p63, Modulates Keratinocyte Differentiation through Regulation of p63alpha mRNA Translation. | 32243883 |
| 2020-07-25 11:23:00 | The findings indicate that HuR regulates autophagy by modulating ATG16L1 translation via interaction with circPABPN1 in the intestinal epithelium. | 31932481 |
| 2020-07-11 11:34:00 | Mitochondrial localization of PABPN1 was observed in the muscle fibers of patients with Ooulopharyngeal muscular dystrophy. Moreover, abnormal accumulation of PABPN1 on the inner membrane of mitochondria and reduced expression of OXPHOS complexes were detected in the muscle fibers of transgenic mice expressing expanded human PABPN1 with a 13-alanine stretch. | 30894671 |
| 2020-02-08 11:03:00 | We demonstrate that guanabenz acetate (GA) increases both the phosphorylation of the eukaryotic translation initiation factor 2alpha subunit and the splicing of Xbp1, key components of the UPR. Altogether these data show that modulation of protein folding regulation is beneficial for Oculopharyngeal muscular dystrophy (OPMD) and promote the further development of GA or its derivatives for treatment of OPMD in humans | 30649389 |
| Type | IDs |
|---|---|
| Synonymous | OPMD, PAB2, PABII, PABP-2, PABP2 |
| Gene |
UniProtKB-ID:
PABP2_HUMAN
UniprotKB:
Q86U42
UniParc:
UPI0000D4C2DF,
UPI000006F6E7
EMBL:
BX247976,
AF026029,
CH471078,
BC010939
Ensembl:
ENSG00000100836
KO:
hsa:8106
|
| Nucleutide sequences |
EMBL-CDS:
AAH10939.1,
AAC39596.1,
CAD62310.1,
EAW66167.1,
EAW66168.1
Ensembl_TRS:
ENST00000397276,
ENST00000216727
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000380446,
ENSP00000216727
RefSeq:
NP_004634.1,
NP_001347481.1,
NP_001347480.1
|
| Others |
UniRef100:
UniRef100_Q86U42
UniRef90:
UniRef90_Q86U42
UniRef50:
UniRef50_Q86U42
UniGene:
Hs.707712
CCDS:
CCDS86374.1,
CCDS9592.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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