| Type | Description |
|---|---|
| Definition | glutathione-disulfide reductase |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 12:01:00 | AMPKalpha1 is overexpressed in colorectal cancer (CRC) patient specimens and the high expression is correlated with poor survival. AMPKalpha1 maintains high level of reduced glutathione to keep redox homeostasis under stress conditions, thus promoting CRC cell survival. Mechanistically, AMPKalpha1 regulate the glutathione reductase (GSR) phosphorylation possibly through residue Thr507 which enhances its activity. | 31530934 |
| 2018-04-21 11:24:00 | It has been shown that acute aerobic exercise activates Nrf2 in young men, irrespective of training intensity, but that high-intensity exercise demonstrated a greater effect on increasing glutathione reductase activity which could indicate improved redox potential. | 28693341 |
| 2018-01-06 11:05:00 | GSR expression was higher in TMZ-resistant cells than in sensitive cells. GSR silencing in drug-resistant cells improved the sensitivity of cells to TMZ or cisplatin. Over-expression resulted in resistance. GSR partially prevented the oxidative stress caused by L-buthionine -sulfoximine. The action of GSR in drug resistance is associated with the modulation of redox homeostasis. High GSR correlated with lower survival. | 29105080 |
| 2016-05-07 12:11:00 | Plasma glutathione reductase (GR) activity was correlated with erythrocyte GR activity and the erythrocyte reduced glutathione/glutathione disulfide ratio. A decrease in plasma GR activity was associated with an increase in mortality in septic shock. | 26316444 |
| 2015-12-05 11:22:00 | Glutathione reductase reduces mitochondrial protein mitoNEET [2Fe-2S] clusters. | 25645953 |
| Type | IDs |
|---|---|
| Synonymous | GR, HEL-75, HEL-S-122m |
| Gene |
UniProtKB-ID:
GSHR_HUMAN,
V9HW90_HUMAN
UniprotKB:
P00390,
V9HW90
UniParc:
UPI0001B7C390,
UPI0001B7C391,
UPI000012BBFF,
UPI0001B7C38F,
UPI000014EB71
EMBL:
AB519179,
AC009314,
AY338490,
AF228703,
AC103959,
AB519180,
AF228704,
CH471080,
GQ472231,
AB519181,
FJ224321,
BC069244,
X15722,
AF215848
Ensembl:
ENSG00000104687
KO:
hsa:2936
|
| Nucleutide sequences |
EMBL-CDS:
BAI43438.1,
CAA33744.1,
EAW63445.1,
BAI43437.1,
AAF37572.1,
AAF37574.1,
AAF37573.1,
AAP88037.1,
EAW63443.1,
BAI43439.1,
AAH69244.1,
ACV87206.1,
ACI46013.1
Ensembl_TRS:
ENST00000541648,
ENST00000546342,
ENST00000537535,
ENST00000221130
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000438845,
ENSP00000445516,
ENSP00000444559,
ENSP00000221130
RefSeq:
NP_001182032.1,
NP_001182031.1,
NP_000628.2,
NP_001182033.1
|
| Others |
UniRef100:
UniRef100_P00390
UniRef90:
UniRef90_P00390
UniRef50:
UniRef50_P00390
UniGene:
Hs.271510
CCDS:
CCDS56532.1,
CCDS34877.1,
CCDS56531.1,
CCDS56530.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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