| Type | Description |
|---|---|
| Definition | exosome component 10 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 13:34:00 | Authors engineered cells in which the 3'-->5' exoribonucleases of the exosome complex, DIS3 and EXOSC10, can be rapidly eliminated to assess their immediate roles in nuclear RNA biology. These transcripts are unaffected by the rapid loss of EXOSC10, suggesting that they are rarely targeted to it. | 30840897 |
| 2019-06-15 12:28:00 | Study shows that the catalytic activity of the exosome subunit EXOSC10 contributes to the homologous recombination (HR) pathway by degrading damage-induced lncRNAs and maintaining RNA homeostasis at double-strand breaks (DSBs). Results identify RNA clearance at DSBs as a step in the HR pathway that is required for the assembly of RPA onto the resected ssDNA, which in turn is a prerequisite for controlled DNA resection. | 31086179 |
| 2019-02-23 13:14:00 | Processing of 3' telomerase RNA occurs in two steps with longer forms first being trimmed by RRP6 and shorter forms then being processed by PARN. | 30575725 |
| 2016-10-22 11:55:00 | Rrp6: Integrated roles in nuclear RNA metabolism and transcription termination | 26612606 |
| 2016-08-13 11:47:00 | EXOSC10 can be modified by SUMOylation and identifies a physiological stress where this regulation is prevalent both in vitro and in vivo. | 26857222 |
| Type | IDs |
|---|---|
| Synonymous | PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4 |
| Gene |
UniProtKB-ID:
EXOSX_HUMAN
UniprotKB:
Q01780
UniParc:
UPI0000000CD8,
UPI0000001C90
EMBL:
AL109811,
BC073788,
BC039901,
AJ300188,
CH471130,
L01457,
X66113
Ensembl:
ENSG00000171824
KO:
hsa:5394
|
| Nucleutide sequences |
EMBL-CDS:
CAC15569.1,
EAW71679.1,
AAH39901.1,
CAA46904.1,
AAB59352.1,
AAH73788.1
Ensembl_TRS:
ENST00000304457,
ENST00000376936
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000366135,
ENSP00000307307
RefSeq:
NP_002676.1,
XP_005263532.2,
NP_001001998.1,
XP_016856986.1,
XP_016856984.1
|
| Others |
UniRef100:
UniRef100_Q01780
UniRef90:
UniRef90_Q01780
UniRef50:
UniRef50_Q01780
UniGene:
Hs.632368
CCDS:
CCDS30584.1,
CCDS126.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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