| Type | Description |
|---|---|
| Definition | nuclear mitotic apparatus protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:33:00 | The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics. | 33044554 |
| 2020-10-24 13:55:00 | IFT88 controls NuMA enrichment at k-fibers minus-ends to facilitate their re-anchoring into mitotic spindles. | 31312011 |
| 2020-09-19 16:25:00 | NuMA1 promotes axon initial segment assembly through inhibition of endocytosis. | 31727776 |
| 2020-07-18 10:16:00 | NuMA promoted the initial step of spindle bipolarization in early mitosis | 31782546 |
| 2020-07-11 11:52:00 | Study identified new genes that rescue cell death induced by BMI1 inhibitors and selected NUMA1 for follow-up studies. Results unveiled a novel mitotic mechanism underlying BMI1-associated lethality using CRISPR-Cas9 derived knockouts of NUMA1 in both HAP1 cells and non-small lung cancer cell lines and highlighted a mechanism relying on mitotic arrest upon loss of BMI1 and a new genetic resistance mechanism. | 32343689 |
| Type | IDs |
|---|---|
| Synonymous | NMP-22, NUMA |
| Gene |
UniProtKB-ID:
NUMA1_HUMAN,
Q4LE64_HUMAN,
A0A024R5M9_HUMAN,
Q3SYK8_HUMAN
UniprotKB:
Q14980,
Q4LE64,
A0A024R5M9,
Q3SYK8
UniParc:
UPI00005B7264,
UPI000013DB8B,
UPI000054C919,
UPI000013D0A9,
UPI000287A2E1,
UPI0000072988,
UPI000287A2E3
EMBL:
Z14229,
Z14227,
AB210007,
Z11583,
Z14228,
AP002490,
BC103765,
CH471076,
BC027493,
BC004165,
Z11584
Ensembl:
ENSG00000137497
KO:
hsa:4926
|
| Nucleutide sequences |
EMBL-CDS:
AAH04165.1,
CAA77669.1,
EAW74826.1,
CAA77670.1,
BAE06089.1,
EAW74824.1,
EAW74821.1,
AAI03766.1,
AAH27493.1
Gene_ORFName:
hCG_2017131
Ensembl_TRS:
ENST00000613205,
ENST00000393695,
ENST00000620566,
ENST00000351960,
ENST00000358965
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000260051,
ENSP00000480172,
ENSP00000478624,
ENSP00000377298,
ENSP00000351851
RefSeq:
XP_011543368.1,
XP_011543366.1,
XP_011543358.1,
XP_011543362.1,
XP_024304323.1,
XP_011543360.1,
XP_016873320.1,
NP_001273490.1,
XP_011543367.1,
XP_011543357.1,
XP_016873319.1,
XP_011543361.1,
XP_011543365.1,
XP_011543363.1,
XP_011543359.1,
XP_024304324.1,
XP_006718627.1,
NP_006176.2,
XP_011543364.1,
XP_011543356.1
|
| Others |
UniRef100:
UniRef100_Q14980,
UniRef100_Q3SYK8,
UniRef100_A0A024R5M9
UniRef90:
UniRef90_Q3SYK8,
UniRef90_Q14980,
UniRef90_A0A024R5M9
UniRef50:
UniRef50_Q14980,
UniRef50_Q3SYK8
UniGene:
Hs.325978
CCDS:
CCDS66156.1,
CCDS31633.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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