| Type | Description |
|---|---|
| Definition | phosphatidylinositol-4-phosphate 5-kinase type 1 alpha |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:23:00 | Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates Abeta production by promoting non-amyloidogenic processing of amyloid precursor protein. | 32686865 |
| 2020-11-21 13:33:00 | Type I Phosphatidylinositol-4-Phosphate 5-Kinases alpha and gamma Play a Key Role in Targeting HIV-1 Pr55(Gag) to the | 32376619 |
| 2019-11-02 12:18:00 | The results suggest that PIP5KA is a novel degradative substrate of NEDD4 and that the PIP5KA-dependent phosphatidylinositol 4,5-diphosphate pool contributing to breast cancer cell proliferation through PI3K/Akt activation is negatively controlled by NEDD4. | 29851245 |
| 2019-04-27 12:19:00 | PIP5K1alpha was associated with poor patient outcome in triple-negative BC. It increased expression of pSer-473 AKT and invasiveness of triple-negative MDA-MB-231 cells. Inhibition reduced expression of pSer-473 AKT and its downstream effectors in xenograft tumors. In ER(+) cancer cells, PIP5K1alpha acted on pSer-473 AKT, and was in complexes with VEGFR2, serving as co-factor of ER-alpha to regulate activities of targe... | 30104711 |
| 2018-12-22 11:54:00 | KRAS-specific interactor that mediates oncogenic KRAS signaling and proliferation | 30194290 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
PI51A_HUMAN,
A6PW57_HUMAN
UniprotKB:
Q99755,
A6PW57
UniParc:
UPI000040D7A5,
UPI0000071126,
UPI00000739E5,
UPI000181BFC3,
UPI000006F821
EMBL:
U78575,
AK291015,
BC007833,
AK295691,
U78577,
AL592424,
CH471121,
U78576
Ensembl:
ENSG00000143398
KO:
hsa:8394
|
| Nucleutide sequences |
EMBL-CDS:
AAC50910.1,
BAF83704.1,
BAG58542.1,
AAH07833.1,
AAC50912.1,
EAW53461.1,
AAC50911.1
Ensembl_TRS:
ENST00000441902,
ENST00000368888,
ENST00000349792,
ENST00000368890,
ENST00000409426
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000357883,
ENSP00000357885,
ENSP00000271663,
ENSP00000415648,
ENSP00000386432
RefSeq:
XP_016857930.1,
XP_006711627.1,
XP_024305899.1,
XP_024305897.1,
XP_006711630.1,
XP_006711626.1,
XP_011508351.1,
XP_005245589.1,
XP_011508350.1,
XP_011508345.1,
XP_005245585.1,
XP_011508348.1,
XP_005245587.1,
XP_006711631.2,
XP_011508347.1,
NP_001129109.1,
XP_005245582.1,
XP_024305898.1,
NP_001129108.1,
NP_001129110.1,
XP_016857928.1,
NP_001317618.1,
NP_003548.1,
XP_016857929.1,
XP_005245584.1
|
| Others |
UniRef100:
UniRef100_A6PW57,
UniRef100_Q99755
UniRef90:
UniRef90_Q99755,
UniRef90_Q99755-3
UniRef50:
UniRef50_Q99755-3,
UniRef50_Q99755
UniGene:
Hs.655131,
Hs.661888
CCDS:
CCDS990.1,
CCDS44221.1,
CCDS44219.1,
CCDS44220.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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