| Type | Description |
|---|---|
| Definition | DENN domain containing 2D |
| Date | Results | Publications |
|---|---|---|
| 2018-06-23 11:20:00 | resulted in increased cell motility and invasive ability. Moreover, miR-1246 increased cell motility by directly targeting DENN/MADD Domain Containing 2D (DENND2D) | 27929118 |
| 2016-01-16 10:42:00 | Higher frequency of promoter hypermethylation of DENND2D is associated with gastric cancer. | 24695972 |
| 2014-09-06 11:02:00 | DENND2D is a candidate tumor suppressor gene that was inactivated by promoter hypermethylation in patients with esophageal squamous cell carcinoma and may serve as a novel biomarker of esophageal squamous cell carcinoma. | 24317529 |
| 2014-08-23 11:54:00 | DENND2D is a candidate tumor suppressor gene that is inactivated by promoter hypermethylation in patients with Hepatocellular carcinoma and may serve as a novel biomarker of early recurrence of Hepatocellular carcinoma . | 24189587 |
| 2013-07-13 13:11:00 | Our data show that DENND2D might function as a tumor suppressor-like gene, preventing survival and expansion of cells with genetic damage through apoptosis mechanism. Absence of DENND2D might play a permissive role, as an early event, in tumorigenesis. | 23182661 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
DEN2D_HUMAN,
A0A024R0H5_HUMAN
UniprotKB:
Q9H6A0,
A0A024R0H5
UniParc:
UPI000013F2E6,
UPI000006E1E1
EMBL:
BC004557,
AL355816,
AK026110,
CH471122
Ensembl:
ENSG00000162777
KO:
hsa:79961
|
| Nucleutide sequences |
EMBL-CDS:
AAH04557.1,
BAB15363.1,
EAW56476.1,
EAW56479.1
Gene_ORFName:
hCG_39989
Ensembl_TRS:
ENST00000357640,
ENST00000369752
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000358767,
ENSP00000350266
RefSeq:
XP_011540492.1,
XP_011540491.1,
XP_016857876.1,
XP_006710985.1,
XP_011540489.1,
XP_006710986.1,
XP_016857878.1,
XP_024305659.1,
XP_016857877.1,
NP_001258762.1,
NP_079177.2,
XP_024305658.1,
XP_016857875.1,
XP_024305666.1,
XP_006710987.1,
XP_006710984.2
|
| Others |
UniRef100:
UniRef100_A0A024R0H5,
UniRef100_Q9H6A0
UniRef90:
UniRef90_Q9H6A0
UniRef50:
UniRef50_Q9H6A0
UniGene:
Hs.557850
CCDS:
CCDS831.1,
CCDS60219.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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