| Type | Description |
|---|---|
| Definition | succinate-CoA ligase ADP-forming beta subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:45:00 | SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. | 33230181 |
| 2020-12-05 13:01:00 | Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion. | 32694611 |
| 2018-02-10 10:24:00 | SUCLA2 mutation is associated with Down syndrome and mitochondrial depletion syndrome. | 28749033 |
| 2017-12-09 12:10:00 | The patient's cells lack the SUCLG1 protein, with significantly reduced levels of SUCLA2 and SUCLG2 protein | 27484306 |
| 2017-04-08 12:05:00 | Sucla2 is related to the developmental stages of mouse spermatogenesis. Knockdown of Sucla2 decreases the viability of mouse spermatocytes by inducing apoptosis via decreased mitochondrial function of the cells. | 27766610 |
| Type | IDs |
|---|---|
| Synonymous | A-BETA, A-SCS, MTDPS5, SCS-betaA |
| Gene |
UniProtKB-ID:
SUCB1_HUMAN,
Q9Y4T0_HUMAN,
E5KS60_HUMAN
UniprotKB:
Q9P2R7,
Q9Y4T0,
E5KS60
UniParc:
UPI000046FDAD,
UPI00001910C1,
UPI000013CFEB
EMBL:
AK315513,
HQ205886,
HQ205879,
AK001847,
AL080096,
HQ205872,
AL157369,
CH471075,
AK001458,
BC027587,
HQ205874,
HQ205897,
HQ205891,
KU178442,
HQ205894,
AB035863,
HQ205882,
HQ205873,
HQ205877,
HQ205871,
HQ205883,
AF058953,
HQ205876
Ensembl:
ENSG00000136143
KO:
hsa:8803
|
| Nucleutide sequences |
EMBL-CDS:
BAA92873.1,
BAG37894.1,
EAX08777.1,
BAA91939.1,
AAH27587.1,
AAC64396.1,
BAA91703.1,
CAB45708.2,
ADP91740.1,
ADP91759.1,
ADP91751.1,
ADP91750.1,
ADP91741.1,
ADP91747.1,
ADP91742.1,
ADP91739.1,
ADP91754.1,
ADP91762.1,
ADP91745.1,
ADP91744.1,
ALQ33900.1,
ADP91765.1
Ensembl_TRS:
ENST00000646932,
ENST00000643584
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000494360,
ENSP00000494987
RefSeq:
NP_003841.1
|
| Others |
UniRef100:
UniRef100_Q6N0B1,
UniRef100_Q9P2R7
UniRef90:
UniRef90_Q9P2R7
UniRef50:
UniRef50_Q9P2R7
UniGene:
Hs.743361
CCDS:
CCDS9406.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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