| Type | Description |
|---|---|
| Definition | leucyl-tRNA synthetase |
| Date | Results | Publications |
|---|---|---|
| 2020-09-12 16:05:00 | Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond. | 32232361 |
| 2020-05-23 12:32:00 | this study provides evidence for a role of leucyl-tRNA synthetase 1 (LARS1) in glucose-dependent control of leucine usage. | 31780625 |
| 2018-01-27 11:17:00 | Leucyl-tRNA synthetase (LRS) is a leucine sensor of the mTORC1 pathway. | 28963468 |
| 2017-10-28 10:57:00 | The results showed a decrease in autophagy on addition of leucine, demonstrating crosstalk between leucine sensing, LRS translocation, RagD interaction, and mTORC1 activation. | 28882589 |
| 2015-08-08 10:35:00 | the KMSKS catalytic loop affects the aminoacylation and editing capacities of leucyl-tRNA synthetase | 25817995 |
| Type | IDs |
|---|---|
| Synonymous | HSPC192, ILFS1, LARS1, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS, hr025Cl |
| Gene |
UniProtKB-ID:
SYLC_HUMAN,
B4E266_HUMAN,
B4DER1_HUMAN,
A0A6I8PL42_HUMAN
UniprotKB:
Q9P2J5,
B4E266,
B4DER1,
A0A6I8PL42
UniParc:
UPI00017A7093,
UPI000067C9E5,
UPI00017A8669,
UPI00020652FA,
UPI0000037316,
UPI00017A6C22
EMBL:
AY513284,
BC150213,
AK293750,
AB037773,
AY926480,
CH471062,
BC152422,
AK304134,
BC151214,
AC091887,
BC131798,
AK295874,
AC091959,
D84223
Ensembl:
ENSG00000133706
KO:
hsa:51520
|
| Nucleutide sequences |
EMBL-CDS:
BAG58672.1,
AAI51215.1,
AAX10025.1,
AAI52423.1,
AAI50214.1,
EAW61848.1,
BAA92590.1,
AAT08037.1,
AAI31799.1,
BAA95667.1,
BAG65028.1,
BAG57172.1
Ensembl_TRS:
ENST00000274562,
ENST00000674174,
ENST00000510191,
ENST00000394434,
ENST00000674447,
ENST00000674270
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000426005,
ENSP00000274562,
ENSP00000377954,
ENSP00000501434,
ENSP00000501376,
ENSP00000501365
RefSeq:
NP_057544.2,
NP_064502.9,
NP_001304893.1,
NP_001304894.1,
XP_011535958.1
|
| Others |
UniRef100:
UniRef100_Q9P2J5,
UniRef100_A0A6I8PL42,
UniRef100_B4E266,
UniRef100_B4DER1
UniRef90:
UniRef90_Q9P2J5,
UniRef90_Q5R614
UniRef50:
UniRef50_Q9P2J5
UniGene:
Hs.432674
CCDS:
CCDS34265.1,
CCDS83029.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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