| Type | Description |
|---|---|
| Definition | ribosomal protein S6 kinase A2 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 12:31:00 | Elevated ribosomal protein S6 kinase A2 (RSK3) expression is responsible for BET bromodomain inhibitors (BETi) resistance. Proto-Oncogene Proteins c-jun (JunD)-dependent RSK3 transcription mediates BETi resistance. JunD/RSK3 signalling correlates to BET inhibition sensitivity. Loss of BRD4/FOXD3/miR-548d-3p axis enhances JunD/RSK3 signalling and determines BET inhibition resistance. | 31937753 |
| 2018-05-19 12:12:00 | Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2; MCC = mutated in colorectal cancer protein) | 29144123 |
| 2016-11-12 10:35:00 | RSK1 and 3 but not RSK2 are down-regulated in breast tumour and are associated with disease progression. RSK may be a key component in the progression and metastasis of breast cancer. | 26977024 |
| 2014-12-20 10:11:00 | Data indicate that S6 kinase 2 (S6K2) can phosphorylate histone H3 at position Thr45, which may play a role during cell proliferation and/or differentiation. | 23564320 |
| 2014-09-13 12:14:00 | Kinome screening revealed RPS6KA2 expression, in human pancreatic cancer cells, protects against erlotinib induced apoptosis. | 24403857 |
| Type | IDs |
|---|---|
| Synonymous | HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, p90RSK2, pp90RSK3 |
| Gene |
UniProtKB-ID:
KS6A2_HUMAN,
B7Z3B5_HUMAN,
X5D337_HUMAN
UniprotKB:
Q15349,
B7Z3B5,
X5D337
UniParc:
UPI0004437D72,
UPI000006DAD2,
UPI000020D48C,
UPI00006C21AA,
UPI0000EE2084
EMBL:
X85106,
L07598,
AL023775,
AK295674,
CH471051,
BC002363,
AK095751,
AL159163,
AB209116,
KJ535080,
AL022069,
Z98049
Ensembl:
ENSG00000071242
KO:
hsa:6196
|
| Nucleutide sequences |
EMBL-CDS:
AAH02363.1,
CAI20579.1,
CAA59427.1,
BAD92353.1,
CAI19651.1,
AAC82496.1,
BAG53121.1,
EAW47522.1,
BAH12151.1,
AHW56719.1
Gene_ORFName:
hCG_2029617
Ensembl_TRS:
ENST00000265678,
ENST00000503859,
ENST00000405189,
ENST00000481261
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000427015,
ENSP00000265678,
ENSP00000422484,
ENSP00000386050
RefSeq:
NP_001305867.1,
NP_001006933.3,
NP_066958.2,
XP_006715612.1,
NP_001305866.1,
NP_001305865.2
|
| Others |
UniRef100:
UniRef100_Q15349,
UniRef100_B7Z3B5,
UniRef100_X5D337
UniRef90:
UniRef90_Q15349,
UniRef90_X5D337
UniRef50:
UniRef50_X5D337,
UniRef50_Q15349
UniGene:
Hs.655277
CCDS:
CCDS5294.1,
CCDS83148.1,
CCDS34570.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员