Type | Description |
---|---|
Definition | VPS41 subunit of HOPS complex |
Date | Results | Publications |
---|---|---|
2020-12-19 13:43:00 | Loss-of-Function Variants in HOPS Complex Genes VPS16 and VPS41 Cause Early Onset Dystonia Associated with Lysosomal Abnormalities. | 32808683 |
2020-02-29 10:05:00 | Here, the authors show that Vps8 overexpression inhibits homotypic fusion and vacuole protein sorting (HOPS)-dependent trafficking routes including late endosome maturation, autophagosome-lysosome fusion, crinophagy and lysosome-related organelle formation. Mechanistically, Vps8 overexpression abolishes the late endosomal localization of HOPS-specific Vps41/Lt and prevents HOPS assembly. | 31194677 |
2019-05-11 10:18:00 | Our results indicate that an ARF-like GTPase gene product, ARL-8, mitigates endocytic Ab neurodegeneration in a VPS-41-dependent manner, rather than through RAB-7 and AP3 as with alpha-synuclein..we demonstrate that the LC3 orthologue, LGG-2, plays a critical role in Ab toxicity with ARL-8. | 30508205 |
2017-10-28 11:24:00 | VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction | 28931724 |
2015-10-10 11:51:00 | VPS41 subunit of HOPS complex was defined to be the major partner for interacting with RILP. | 25445562 |
Type | IDs |
---|---|
Synonymous | HVPS41, HVSP41, hVps41p |
Gene |
UniProtKB-ID:
VPS41_HUMAN
UniprotKB:
P49754
UniParc:
UPI000000DAB7,
UPI000185D57F,
UPI0000246C59
EMBL:
U87281,
U87309,
AC011292,
L40398,
BC044851,
AC004850,
AC005247
Ensembl:
ENSG00000006715
KO:
hsa:27072
|
Nucleutide sequences |
EMBL-CDS:
AAB47563.1,
AAH44851.1,
AAB47758.1,
AAC42004.1
Ensembl_TRS:
ENST00000395969,
ENST00000310301
|
Protein sequencees |
Ensembl_PRO:
ENSP00000379297,
ENSP00000309457
RefSeq:
NP_055211.2,
XP_016867477.1,
NP_542198.2
|
Others |
UniRef100:
UniRef100_P49754
UniRef90:
UniRef90_P49754
UniRef50:
UniRef50_P49754
UniGene:
Hs.592184
CCDS:
CCDS5458.2,
CCDS5457.1
|
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Refseq |
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