| Type | Description |
|---|---|
| Definition | 3-hydroxyacyl-CoA dehydratase 3 |
| Date | Results | Publications |
|---|---|---|
| 2018-10-11 12:36:00 | HACD3 (PTPLAD1) is a new candidate gene for type-2 diabetes risk. HACD3 deletion decreases the autophosphorylation of insulin receptor in vitro. HACD3 may regulate the activity of CDK2 and RAB5C.Overexpression of HACD3 inhibits the tyrosine phosphorylation of CDK2 and RAB5C. HACD3 stimulates the physical association of insulin receptor with RAB11A and may regulate the recycling of insulin receptor to the plasma membrane. | 30300385 |
| 2015-07-06 12:12:00 | Our results indicate that PTPLAD1 (HACD3) is in complex with insulin receptor (IR) in rat's liver and in human HEK293 cells. SiRNA-mediated partial knockdown of PTPLAD1 increased level of IR tyrosine phosphorylation and affect IR endocytosis. PTPLAD1 depletion strongly enhanced insulin effect on Glut2 translocation in HEK293 cells similar to the increase in AKT-ser473 phosphorylation. [PTPLAD1] | 25687571 |
| 2012-07-07 11:57:00 | Genes in the erythroid differentiation and cell cycle regulation pathways influence interindividual variation in RBC indices. Our results provide insights into the molecular basis underlying variation in RBC traits. | 22560525 |
| 2010-01-21 00:00:00 | The structure of the B-IND1 gene promoter region was determined. | 16516406 |
| 2010-01-21 00:00:00 | These results suggest that an Hsp90-dependent chaperone pathway incorporating hB-ind1 is involved in protein folding in the membranous web for the circumvention of the UPR and that it facilitates HCV replication | 19656872 |
| Type | IDs |
|---|---|
| Synonymous | B-IND1, BIND1, HSPC121, PTPLAD1 |
| Gene |
UniProtKB-ID:
HACD3_HUMAN,
H3BRL8_HUMAN
UniprotKB:
Q9P035,
H3BRL8
UniParc:
UPI00001FE6BA,
UPI00001D6EF0,
UPI00024674A7
EMBL:
DQ251107,
AK074857,
AC027220,
BC047685,
AK299234,
AJ271091,
BC035508,
AK074898,
AF161470,
BC019873,
AK027421,
AC011846,
BC058912
Ensembl:
ENSG00000074696
KO:
hsa:51495
|
| Nucleutide sequences |
EMBL-CDS:
AAH58912.1,
AAH47685.1,
BAG61266.1,
AAF29085.1,
AAH35508.1,
AAH19873.1,
CAB69070.1,
BAC11249.1,
ABB83547.1,
BAB55101.1,
BAC11277.1
Ensembl_TRS:
ENST00000261875,
ENST00000442729,
ENST00000569894,
ENST00000566074,
ENST00000566511,
ENST00000562901
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000261875,
ENSP00000392491,
ENSP00000456300,
ENSP00000455587,
ENSP00000454873,
ENSP00000455686
RefSeq:
NP_057479.2,
XP_011519966.1
|
| Others |
UniRef100:
UniRef100_H3BS72,
UniRef100_Q9P035
UniRef90:
UniRef90_Q9P035,
UniRef90_H0VP33
UniRef50:
UniRef50_Q9P035
UniGene:
Hs.512973
CCDS:
CCDS45282.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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